CAS: 532-55-8; Benzoyl Isothiocyanate

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CAS号333-20-0 硫氰酸钾 | CAS号98-88-4 苯甲酰氯 | CAS号75732-41-1 benzoic acid,te... | CAS号197312-72-4 triisopropylsil... | CAS号87544-56-7 N-[[3-benzoyl-1... | CAS号75-36-5 乙酰氯 | CAS号65-85-0 苯甲酸 | CAS号540-72-7 硫氰酸钠 | CAS号2078-12-8 trimethylsilyl ... | CAS号1077628-67-1 1-(3-Methoxy-4-... | CAS号111416-65-0 N-[4-(benzoylca... | CAS号3696-22-8 (4-硝基苯基)硫脲 | CAS号4104-75-0 1-甲基-1-苯基硫代脲 | CAS号55040-86-3 2-吗啉-4-基-4-苯基噻唑... | CAS号4921-86-2 1-苯甲酰-3-(2-吡啶基)-2-硫脲 | CAS号3676-72-0 N2-苯甲酰基-D-鸟苷 | CAS号55752-58-4 2,3-二甲基苯基硫脲 | CAS号4921-82-8 1-苯酰基-3-苯基硫脲 | CAS号463-58-1 羰基硫

苯甲酰氯置于potassium Thioacyanate体系中,用 乙腈 作为反应溶剂,化学反应生成 苯甲酰基异硫氰酸酯
参考文献:可持续铂和钯回收的进展:新型二氧化硅锚定酰基硫脲吸附剂展现出卓越的吸附效率和选择性
标题:可持续铂和钯回收的进展:新型二氧化硅锚定酰基硫脲吸附剂展现出卓越的吸附效率和选择性
摘要:这项研究解决了铂族金属 (Pgm) 自然资源枯竭的紧迫问题,这是由于铂族金属在现代应用中的广泛使用以及对可再生能源技术的需求不断增加所推动的.随着传统来源的减少,从替代来源寻找经济可行的回收方法变得至关重要.我们的重点是创新高效回收策略,从而开发了两种新型二氧化硅锚定吸附剂:Dtmsp-Bt-Sg(一种高效酰基硫脲吸附剂)和 Btmspa-Sg(一种二氧化硅锚定胺吸附剂).我们在 Pgm 采矿废水条件下进行了全面的实验,改变了吸附剂质量,Ph,浓度,接触时间,竞争离子和体积等参数. Dtmsp-Bt-Sg 表现出卓越的性能,在 Ph 2,0.5 G L-1剂量和 5 Mg L-1浓度下,Pt 的最大吸附效率 >98%,Pd 的最大吸附效率 >99%.相比之下,在相同条件下,Btmspa-Sg 分别回收了 <56% 和 <89% 的 Pt 和 Pd.使用 Langmuir 和 Freundlich
DOI:10.1039/d3Ra08169A

专利信息

专利号:US-6872727-B1
优先权日:1999-08-26
标 题:Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation
发明人：HERRMANN KONRAD; LEISTNER SIEGFRIED; WIPPICH PETRA
权利人:PRIVATES INST FUR BIOMEDIZINIS
摘要:Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.

专利号:US-2009099218-A1
优先权日:2007-09-17
标题 :Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs
发明人：KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
权利人:KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
摘要:This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.

专利号:US-10626091-B2
优先权日:2014-10-01
标 题 :Process for the preparation of enzalutamide
发明人：CHIVUKULA KAMESWAR RAO; KARUTURI VEERA VENKATESWARA RAO; BENDA SRINIVAS; ANKE RAMACHANDRA; GAJULA DHARMAPURI; MOTURU VENKATA RAMA KRISHNA MURTHY; INDUKURI VENKATA SUNIL KUMAR; GORANTLA SEETA RAMA ANJANEYULU; CHAVA SATYANARAYANA
权利人:LAURUS LABS LTD
摘要:The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.

专利号:US-7595326-B2
优先权日:2005-04-18
标题 :Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (BPU) sulfur analogs
发明人：KHAN SAEED R; HALLUR GURULINSAPPA; HIDALGO MANUEL; JIMENO ANTONIO
权利人:CHAMPIONS BIOTECHNOLOGY INC
摘要:A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6 n and 7 d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6 n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6 n retained significant ability to inhibit tubulin assembly, with an IC 50 of 2.1 μM.

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.