CAS: 5292-53-5; Diethyl Benzylidenemalonate

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📜(3-Ethoxy-1-Phenylprop-2-Ynyl) Ethyl Carbonate置于platinum(II) Chloride体系中,用 二氯甲烷 作为反应溶剂,以68%的收率获得产物亚苯甲基丙二酸二乙酯
参考文献:炔丙酯的重排:基于金属的 (E)-和 (Z)-Knoevenagel 衍生物的立体有择合成
标题:炔丙酯的重排:基于金属的 (E)-和 (Z)-Knoevenagel 衍生物的立体有择合成
摘要:烷氧基取代的炔丙酯在 Pt(II) 和 Cu(I) 催化剂存在下进行区域选择性 1,3-酰氧基迁移,从而可以制备 α-亚基-β-酮和丙二酸酯.该反应也被证明是立体发散的,因为 Pt(II) 和 Cu(I) 催化剂以互补的 Z/e 选择性进行异构化.此外,炔基共轭的 Knoevenagel 产品是由(双炔基)甲基乙酸酯生产的.在这种情况下,反应是化学选择性的,因为 1,3-乙酰基迁移优先通过烷氧基炔基而不是苯炔基.所得的 (E)-炔烃单元在金属催化下环化成呋喃环,反应生成铜 (I) 卡宾物质.
DOI:10.1021/ja072864R

专利信息

专利号:US-5945548-A
优先权日:1995-03-03
标题:Process for the synthesis of α-substituted acrylic acids and their application
发明人：DUHAMEL PIERRE; DUHAMEL LUCETTE; DANVY DENIS; MONTEIL THIERRY; LECOMTE JEANNE-MARIE; SCHWARTZ JEAN-CHARLES
权利人:BIOPROJECT SOC CIV
摘要:Process for the synthesis of α-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##

专利号:US-4567265-A
优先权日:1984-01-16
标题:Cyclopropanoid cyanoesters and method of making same
发明人：BABLER JAMES H
权利人:UNIV LOYOLA CHICAGO
摘要:Cyclopropanoid cyanoesters of the formula: where R' is -CH3 or -CH2CH3, and A is (a) -H, or (b) A, B represents an aliphatic group joined to a carbon atom on the cyclopropanoid ring, thereby forming a spiro group, A, B being selected from structures having the formula: (i) -(CH2)n-, wherein n=3, 4, or 5, and (ii) -(CH2)2-Y-(CH2)2-, wherein Y is NCH3, O, or S); and, when A is -H, B is selected from the group consisting of: +TR (CH3)2CHCH2. are disclosed. These compositions are useful in the synthesis of pyrethroids. A process for synthesis of cyclopropanoid cyanoesters by reacting 2-nitropropane with cyanoesters of the general formula: is also disclosed and claimed.

专利号:US-6051704-A
优先权日:1996-07-22
标题:Synthesis of macrocyclic tetraamido-N ligands
发明人：GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
权利人:UNIV CARNEGIE MELLON
摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

专利号:US-7598399-B2
优先权日:2005-11-30
标 题 :Methods for synthesis of 3-amino-1-arylpropyl indoles
发明人：CONNOLLY TERRENCE JOSEPH; FARRELL ROBERT P; HUMPHREYS ERIC ROY; LYNCH STEPHEN M; SARMA KESHAB
权利人:ROCHE PALO ALTO LLC
摘要:A method comprising:n hydrogenating an indole propionamide compound of formula h nn nwith vitride, to form an aminopropyl indole compound of formula in n nwherein m, Ar, R 1 and R 2 are as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands