CAS: 42097-42-7; 2-(Hydroxymethyl)-6-Methylpyridin-3-Ol

该化合物是属于衍生物类的有机化合物,其特点是以氢氧基组和甲基组替代的环,这对其化学特性有帮助;该化合物的特点是,由于存在氢氧基组,能够参与氢联结,这可以提高其在极地溶剂中的溶解性;甲基组可影响化合物的性能和再活动;典型的是,基衍生物展示生物活动,该化合物可能用于制药或生物化学探测,其结构特征表明它可能与各种生物目标发生相互作用,尽管需要进一步研究具体的生物活动;此外,该化合物的稳定性,再活性和潜在毒性将取决于其特定环境和条件;

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61548-52-5 66497-42-5 14162-88-0

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

5-Hydroxy-2-methylpyridine formaldehyd 3-hydroxy-6-methyl-2-pyridinecarboxylic acid 3-methoxy-2-methoxymethyl-6-methyl-pyridine 2-chloromethyl-6-methyl-pyridin-3-ol hydr°Chloride 2-Phenyl-2-oxo-4-H-6-methyl-(3,2-d)pyrido-1,3,2-dioxaphosphorinan 3-hydroxy-6-methyl-2-pyridinecarboxylic acid 3-hydroxy-6-methylpicolinaldehyde

合成工艺路线路线简述

    📜6-甲基吡啶-3-磺酸置于氢氧化钾,Sodium Hydroxide,水,铁粉体系中,化学反应生成 3-羟基-6-甲基-2-吡啶甲醇
    参考文献:34.对吡啶化学的贡献.第二部分 3-和5-羟基-2-甲基吡啶,以及5-羟基-2-甲基吡啶与甲醛在碱性介质中的缩合
    标题:34.对吡啶化学的贡献.第二部分 3-和5-羟基-2-甲基吡啶,以及5-羟基-2-甲基吡啶与甲醛在碱性介质中的缩合
    摘要:
    DOI:10.1039/jr9470000132

    海关参考信息

    专利信息


    专利号:US-8735586-B2
    优先权日:2007-06-26
    标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
    发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
    权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

    专利号:EP-2173747-B1
    优先权日:2007-06-26
    标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
    发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
    权利人:SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

    专利号:US-2010261909-A1
    优先权日:2007-06-26
    标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

    专利号:WO-2009000413-A1
    优先权日:2007-06-26
    标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

    专利号:EP-2173721-B1
    优先权日:2007-06-26
    标 题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

    专利号:KR-20100023907-A
    优先权日:2007-06-26
    标题:Regioselective Copper Catalytic Synthesis of Benzimidazole and Azabenzimidazole

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: James R Vyvyan, Et Al. Suzuki-Miyaura Cross-Coupling Of 3-Pyridyl Triflates With 1-Alkenyl-2-Pinacol Boronates. Synthesis (Stuttg). 2010 Nov;2010(21):3637-3644.

    合成参考文献


    参考文献:10.1055/s-0040-1706870
    摘要:Sabot C, Mabrouki A, Le Nahenec-Martel P, Kriaa A, Hedhli A, Renard P. Dearomatization of a 3-Hydroxypyridine Through an Unexpected Oxidative Deformylation Process: An Entry to Azacyclohexadienones. Synlett. 2020 Jul 13;31(15):1497–500. doi: 10.1055/s-0040-1706870.
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