CAS: 403-41-8; 1-(4-Fluorophenyl)Ethyl Alcohol

该化合物是一种有机化合物,其特征是含有含氢氧乙基链的含氟联苯组,该化合物具有苯结构,氟原子在芳香环上与羟基组处于平行状态,影响其化学特性和反应力,在室温上一般是一种无色的淡黄色液体,在水中呈现出由于极地氢化物组而导致的中等溶解性,同时在有机溶剂中溶解.氟化物的存在可增强化合物的脂性并改变其生物活动,使其对药用化学和材料科学感兴趣.此外,1-(4-氟联苯)乙醇可以参与各种化学反应,包括核生殖器替代和氧化过程,这可以导致形成其他功能化衍生物.其独特的结构和特性使它成为研究及药物和农用化学剂潜在应用的宝贵化合物.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

methyl magnesium iodide 4-fluorobenzaldehyde methylmagnesium bromide 1-(4-fluorophenyl)ethanone 1-(4-fluorophenyl)ethanone -buten-(1)1.1-Dichlor-3--buten-(1) 1-(1-chloroethyl)-4-fluorobenzene 4,4'-(1,1'-oxybis(ethane-1,1-diyl))bis(fluorobenzene)

合成工艺路线路线简述

  • 合成目标产物 1-(4-Fluorophenyl)Ethanol 主要起始原料 4-Fluoroacetophenone
  • (文献来源)合成步骤主要原料 4-Fluoroacetophenone
📜氟苯置于甲醇,Aluminum (Iii) Chloride,Sodium Tetrahydroborate体系中,化学反应 3.25H,反应生成 1-(4-氟苯基)-1-乙醇
参考文献:Substituted Cyclic Carboxamide And Urea Derivatives As Ligands Of The Vanilloid Receptor
标题:Substituted Cyclic Carboxamide And Urea Derivatives As Ligands Of The Vanilloid Receptor
摘要:取代环状羧酰胺和脲化合物,其制备方法,含有这些化合物的药物组合物,以及利用这些化合物治疗和/或抑制由辣椒素受体1介导的疼痛和其他病症的用途.

海关参考信息

专利信息


专利号:US-7763734-B2
优先权日:2006-04-19
标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis
发明人:WOLF CHRISTIAN; LIU SHUANGLONG
权利人:UNIV GEORGETOWN
摘要:One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.

专利号:WO-2012173504-A2
优先权日:2011-06-15
标 题 :Method for synthesis of the substituted azetidinones and intermediates for their synthesis

专利号:US-4346242-A
优先权日:1980-06-05
标 题:Method for preparing substituted meta-phenylalkoxynitrobenzenes
发明人:SPATZ DAVID M
权利人:AMERICAN CYANAMID CO
摘要:Methods for the preparation of substituted meta-phenylalkoxynitrobenzenes and their use as starting materials for the synthesis of herbicidal meta-phenylalkoxyphenylurea.

专利号:CN-108101741-A
优先权日:2017-12-05
标题 :A method for the tandem synthesis of chiral alcohols by hydration/asymmetric hydrogenation of alkynes

专利号:US-8148554-B2
优先权日:1998-06-17
标 题:Methods and compositions for use in treating cancer
发明人:SELETSKY BORIS M; YU MELVIN J; ZHENG WANJUN
权利人:SELETSKY BORIS M; YU MELVIN J; ZHENG WANJUN; EISAI R&D MAN CO LTD
摘要:The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.

专利号:CN-104262095-A
优先权日:2014-10-12
标题:Synthesis of R-1-(4-fluorophenyl)ethanol and its esters

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Lipshutz, B. H.; Ghorai, S., Science of Synthesis Knowledge Updates, (2014) 2, 178.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 85.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 96.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 94.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 92.
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