CAS: 402-66-4; 5-Fluoronicotinic Acid

相似化合物

39891-04-8 455-70-9 696-42-4

上下游产品

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3,5-二甲基吡啶置于氢氧化钾,Potassium Permanganate,Tetrafluoroboric Acid,氯化亚砜,氨,溴,亚硝酸异戊酯体系中,用 水,1,2-二氯乙烷 作为反应溶剂,化学反应 10.58H,反应生成 5-氟烟酸
参考文献:A General Synthesis Of Substituted Fluorenones And Azafluorenones
标题:A General Synthesis Of Substituted Fluorenones And Azafluorenones
摘要:
DOI:10.1021/jo00250A019

专利信息

专利号:US-5204478-A
优先权日:1992-08-20
标题 :Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
发明人：JENNINGS REX A
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.

专利号:WO-9404501-A1
优先权日:1992-08-20
标题 :Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

专利号:JP-3287845-B2
优先权日:1992-08-20
标 题 :Method for improving the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

专利号:NZ-254628-A
优先权日:1992-08-20
标 题:Synthesis of 2,6-dichloro-5-fluoronicotinic acid or -nicotinoyl chloride

专利号:CA-2141046-C
优先权日:1992-08-20
标 题:Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride