CAS: 31645-39-3; N,N′-Bis(2-Chloroethyl)Phosphorodiamidic Acid

📜Aldoifosfamide置于buffer Ph 7.4体系中,用 重水 用作溶剂,化学反应生成帕利伐米
参考文献:Phosphorus-31 NMR Studies Of The Kinetics Of Bisalkylation By Isophosphoramide Mustard: Comparisons With Phosphoramide Mustard
标题:Phosphorus-31 NMR Studies Of The Kinetics Of Bisalkylation By Isophosphoramide Mustard: Comparisons With Phosphoramide Mustard
摘要:31P Nuclear Magnetic Resonance Spectroscopy Was Used To Measure The Pka (4.28 +/-0.2) Of Isophosphoramide Mustard (Ipm) At 20 Degrees C And To Study The Kinetics And Products Of The Decomposition Of Ipm At A Solution Ph Value Of Ca. 7.4 And At Temperatures Between 20 And 47 Degrees C In The Presence Of Nucleophilic Trapping Agents. At 37 Degrees C,The Half-Life For The First Alkylation Was Ca. 77 Min And Ca. 171 Min For The Second Alkylation; These Data May Be Compared With Those For Phosphoramide Mustard (Engle,T.W.; Zon,G.; Egan,W.J. Med. Chem. 1982,25,1347),Wherein The Half-Lives For The First And Second Alkylations Are Approximately The Same (18 Min). The Rate Of Fragmentation Of Aldoifosfamide To Ipm And Acrolein Was Also Studied By NMR Spectroscopy (Ph 7.0; 37 Degrees C; 0.07 M Phosphate); Under The Noted Conditions,The Half-Life Of Aldoifosfamide Was Found To Be Ca. 60 Min.
Doi:10.1021/jm00128A018

专利信息

专利号:WO-2024081775-A1
优先权日:2022-10-14
标 题:Synthesis of 6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
发明人：WOERLY ERIC MICHAEL; LINDSAY-SCOTT PETER JAMES
权利人:LILLY CO ELI
摘要:The present invention provides improved reaction schemes and novel reaction intermediates for the synthesis of molecules useful as O-GlcNAcase (OGA) inhibitors.

专利号:EP-4530360-A1
优先权日:2023-09-29
标题:Method for spatial barcoding
发明人：BOSIO ANDREAS; PERBOST MICHEL; PINARD DR ROBERT; DEVRIES ANTHONY; KINKHABWALA ALI
权利人:MILTENYI BIOTEC BV & CO KG
摘要:One object of the invention was to provide a method for spatial synthesis of oligonucleotides of known sequence (such as barcode sequences) in a biological sample comprising the steps: (A) Providing a biological sample comprising target cells comprising nucleic acids. (B) Identify target cells in said biological sample and assign each target cell a spatial position within said biological sample, thereby creating a map of the target cells (Figure 8) (C) Adding nucleotides comprising a protecting unit at their 3' positions and a template independent transferase to the biological sample, thereby incorporating said nucleotides to each free 3' hydroxyl group of each nucleic acid in the biological sample (D) Synthesizing an oligonucleotide of known sequence comprising the steps: (i) spatially illuminating the position of the target cells with light, thereby inducing cleavage of the protecting unit from the nucleic acids comprised in said target cells and generating free 3' hydroxyl groups at the 3'ends of said nucleic acids (ii) providing nucleotides comprising a protecting unit at their 3' positions and a template independent transferase, thereby incorporating said nucleotide to the free 3' hydroxyl groups of the 3'ends of said nucleic acids. (E) Repeating step D at least 3 times, thereby generating nucleic acids comprising an oligonucleotide of known sequence.

专利号:US-2022347663-A1
优先权日:2021-04-27
标题 :Ferrosilicate ssz-70 molcular sieve, its synthesis and use
发明人：LEW CHRISTOPHER MICHAEL; CHEN CONG-YAN; ZHAN BI-ZENG; ZONES STACEY IAN
权利人:CHEVRON USA INC
摘要:A ferrosilicate molecular sieve having the framework structure of SSZ-70 and a method of making the same is disclosed. The ferrosilicate molecular sieve can be used in processes for dewaxing paraffinic hydrocarbon feedstocks.

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-9254298-B2
优先权日:2008-07-31
标 题 :Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
发明人：WALIGORA FRANK W; AMEDIO JR JOHN C
权利人:ZIOPHARM ONCOLOGY INC
摘要:Disclosed herein are formulations and methods of manufacture of compounds of formula (E): n nwherein X and Y independently represent leaving groups; and A + is an ammonium cation.

专利号:CN-114206897-A
优先权日:2019-05-08
标 题:Convergent liquid phase synthesis of oligonucleotides