CAS: 21397-08-0; 2-Chloro-3-Fluoroaniline

上下游产品

CAS号21397-07-9 2-氯-3-氟硝基苯 | CAS号95-51-2 2-氯苯胺 | CAS号602-03-9 2,3-二硝基苯胺 | CAS号863870-76-2 2-氯-3-氟-N,N-二乙基... | CAS号402-67-5 间氟硝基苯 | CAS号1070892-66-8 N-(3-氟-2-氯-苯基)-甲酰胺

二硝基苯胺置于盐酸,Tin(Ll) Chloride体系中,化学反应生成2-氯-3-氟苯胺
参考文献:一些芳香族氟化合物.
标题:一些芳香族氟化合物.
摘要:
Doi:10.1021/jm00301A063

专利信息

专利号:WO-2023071314-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:US-12331058-B2
优先权日:2021-10-29
标 题:SHP2 and CDK4/6 dual-target inhibitory compound and pharmaceutical composition containing the same
发明人：WU XIAOXING; CHEN XIAOYU; LI WENQIANG; Shu Chengxia; LUO GUANGMEI; YANG KEXIN
权利人:UNIV CHINA PHARMA
摘要:The present invention belongs to the field of medicinal chemistry, and particularly relates to synthesis, a preparation method and the use of an inhibitor containing dual targets SHP2 and CDK4/6, wherein the inhibitor comprises three compounds of general formulas I-III and pharmaceutically acceptable salts, enantiomers, diastereomers, tautomers, solvates, polymorphs or prodrugs thereof. According to the present invention, a class of brand-new SHP2 and CDK4/6 dual-target inhibitors are prepared by means of a pharmacophore fusion and reasonable drug design method, so that the problems of drug resistance, poor drug effect, etc., of the existing SHP2 inhibitor and CDK4/6 inhibitor are solved; the great significance of the present invention is providing the first SHP2 and CDK4/6 dual-target inhibitor, which provides a basis for solving the problem of drug resistance of kinase and phosphatase in the later period.

专利号:EP-4410794-A1
优先权日:2021-10-29
标题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:CA-3236558-A1
优先权日:2021-10-29
标 题:Synthesis, preparation method and use of shp2 and cdk4/6 dual-target inhibitory compound

专利号:CN-1158846-A
优先权日:1995-05-09
标题 :Synthesis technology of norfluxacini hydrochloride