📜3-氨基吡啶 以70%的收率获得 参考文献:Giam C. S.; Hauck A. E.,Org. Prep. And Proced. Int.,1977,No 9,9-11 标题:Giam C. S.; Hauck A. E.,Org. Prep. And Proced. Int.,1977,No 9,9-11
专利号:JP-2014523890-A 优先权日:2011-06-30 标题:Novel precursors for the direct synthesis of 18F-fluoromethoxy compounds for PET imaging and the direct radioactive synthesis of protected derivatives of O-([18F] fluoromethyl) tyrosine
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-6225341-B1 优先权日:1995-02-27 标 题:Compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A 权利人:GILEAD SCIENCES INC 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-10995078-B2 优先权日:2013-03-13 标 题:Compounds and compositions for inhibition of FASN 发明人:BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J 权利人:FORMA THERAPEUTICS INC 摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
专利号:US-5639852-A 优先权日:1994-09-01 标 题:Immunostimulatory agents 发明人:RICH DANIEL H; MALKOVSKY MIROSLAV; ANGELL YVONNE M 权利人:WISCONSIN ALUMNI RES FOUND 摘要:Compositions and methods are described for the synthesis of novel analogs of cyclosporin A, and the use of those analogs as immunostimulatory agents.
专利号:US-6710198-B2 优先权日:1998-01-15 标题 :Perfluoro-n-alkylsulfonic acid derivatives 发明人:WACHTLER ANDREAS; DERWENSKUS KARL-HEINZ; MEUDT ANDREAS 权利人:MERCK PATENT GMBH 摘要:Described are bis(perfluoro-n-alkane-sulfonate) compounds, methods for preparing these compounds and use of these compounds, for example as starting materials for the synthesis of chiral and phosphine ligands for transition metal catalysts.
摘要:F. Cruège, G. Girault, S. Coustal, J. Lascombe and P. Rumpf. Bull. Soc. Chim. France 1970, 3889. 参考文献:10.1007/s00894-002-0075-z 摘要:Hennemann M, Clark T. A QSPR-Approach to the Estimation of the p K HB of Six-Membered Nitrogen-Heterocycles using Quantum Mechanically Derived Descriptors. Journal of Molecular Modeling. 2002 Apr 01;8(4):95–101. doi: 10.1007/s00894-002-0075-z.