CAS: 18297-63-7; 1,3-Bis(Trimethylsilyl)Urea

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CAS号57-13-6 尿素 | CAS号999-97-3 六甲基二硅氮烷 | CAS号21149-38-2 2,2,2-三氟-N,N-二(... | CAS号2083-91-2 N-(三甲基硅烷基)二甲胺 | CAS号14246-15-2 Hexanoic acid t... | CAS号18388-84-6 Trimethyl(nonyl... | CAS号18293-71-5 O-三甲基硅基 氯乙酸酯 | CAS号107-46-0 六甲基二硅氧烷 | CAS号1118-02-1 三甲基硅基异氰酸酯 | CAS号999-97-3 六甲基二硅氮烷 | CAS号18146-00-4 三甲基烯丙氧基硅烷 | CAS号76734-92-4 双(三甲基甲硅烷基)丁-2-炔二酸酯 | CAS号681-99-2 三丁基锡乙氰酸酯 | CAS号13688-56-7 甲基丙烯酸三甲基硅烷酯

2,2,2-三氟-N,N-二(三甲硅基)乙酰胺,尿素置于吡啶体系中,化学反应生成六甲基二硅脲
参考文献:甲酰胺和铁硫矿物合成和降解核酸组分
标题:甲酰胺和铁硫矿物合成和降解核酸组分
摘要:我们描述了在铁硫和铁铜硫矿物作为催化剂的情况下,从甲酰胺中一锅合成大量核酸碱基和相关化合物.观测到的主要产物是嘌呤,1H-嘧啶酮,异胞嘧啶,腺嘌呤,2-氨基嘌呤,碳二亚胺,尿素和草酸.异胞嘧啶和 2-氨基嘌呤可以通过 Watson-Crick 和逆转 Watson-Crick 相互作用识别天然核碱基,从而为原始核酸的起源提出了新的假设.由于信息聚合物起源的主要问题是其前体的不稳定性,我们还研究了铁硫和铁铜硫矿物对甲酰胺和水中核寡核苷酸稳定性的影响.所有的铁硫和铁铜硫矿物都刺激了 Rna 的降解.
Doi:10.1021/ja804782E

专利信息

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-5512701-A
优先权日:1995-06-07
标题:Process for the synthesis of vinyl sulfenic acid derivatives
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.

专利号:US-2023287032-A1
优先权日:2020-08-14
标 题:Synthesis of fluorinated nucleotides
发明人：CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO
权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

专利号:US-5606075-A
优先权日:1995-06-07
标 题:Process for the synthesis of benzo[b]thiophenes
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to new processes for the synthesis of 2-aryl benzo[b]thiophenes.

专利号:EP-2030975-A1
优先权日:2007-08-06
标 题:CEFDINIR synthesis process
发明人：MANCA ANTONIO; FILIPPI MAURO; SALA BRUNO MAURIZIO; MONGUZZI RICCARDO AMBROGIO; FOGLIATO GIOVANNI
权利人:ACS DOBFAR SPA
摘要:Cefdinir preparation by synthesis of new key intermediates, isolable as variously solvated species complexed with thiophosphoric acid derivatives or with phosphoric acid derivatives.

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.