CAS: 1721-12-6; 1-(2-Methylpyridin-3-yl)Ethan-1-One

相似化合物

1721-25-1 90086-87-6 2227726-99-8

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CAS号107-02-8 丙烯醛 | CAS号123-54-6 乙酰丙酮 | CAS号3430-16-8 3-溴-5-甲基吡啶 | CAS号97674-02-7 三丁基(1-乙氧基乙烯)锡 | CAS号156-87-6 3-氨基丙醇 | CAS号917-54-4 甲基锂 | CAS号65719-09-7 2-甲基烟酸甲酯 | CAS号1721-23-9 3-氰基-2-甲基吡啶 | CAS号917-64-6 甲基碘化镁 | CAS号1118-66-7 Fluoral-P(=4-氨基... | CAS号101166-73-8 2-甲基-3-吡啶乙腈 | CAS号1977-05-5 2-吡啶-3-乙醇 | CAS号504404-51-7 3-Pyridineethan... | CAS号4116-88-5 3-ethylpyridine...

📜6-Methyl-2-N-Butoxy-5-Acetyl-3,4-Dihydropyran置于aluminum (III) Chloride,Ammonium Acetate,亚甲兰体系中,用 异丙醇 用作溶剂,化学反应 9.0H,以44%的收率获得3-乙酰基-2-甲基吡啶
参考文献:一种2-甲基烟酸酯及其衍生物的制备方法
标题:一种2-甲基烟酸酯及其衍生物的制备方法
摘要:本发明属于精细化学品制备技术领域,公开了一种2‑甲基烟酸酯及其衍生物的制备方法,该方法包括以下步骤:(1)将包括烷基乙烯基醚,1,3‑二羰基化合物以及甲醛类原料在内的原料在60oc~100oc下反应6小时~9小时,分离反应产物得到2‑烷氧基‑3,4‑二氢吡喃衍生物;(2)将2‑烷氧基‑3,4‑二氢吡喃衍生物在氧化剂亚甲基蓝和路易斯酸的作用下,在有机溶剂中与铵盐于一定温度下反应7至10小时,得到2‑甲基烟酸酯或其衍生物.本发明通过对制备方法的整体反应流程设计,反应条件进行改进,与传统2‑甲基烟酸酯及其衍生物的制备方法相比,具有原料廉价易得,产物易分离,步骤简单,工业应用价值大等优点.

专利信息

专利号:US-8664402-B2
优先权日:2011-03-09
标题:Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib
发明人：CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO
权利人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO; ITALIANA SINT SPA
摘要:A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.

专利号:US-8501941-B2
优先权日:2005-02-25
标题 :Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines
发明人：WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D
权利人:WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D; DOGWOOD PHARMACEUTICALS INC
摘要:The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents. Also provided are processes for the preparation of the compounds and their intermediates.

专利号:US-2007105821-A1
优先权日:2005-02-25
标 题 :Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines

专利号:US-2012226040-A1
优先权日:2005-02-25
标题 :Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines

专利号:US-7598379-B2
优先权日:2005-02-25
标 题:Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines

专利号:US-8420813-B2
优先权日:2005-02-25
标题:Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines