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📜衣康酸二甲酯置于9-硼双环[3.3.1]壬烷体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应生成N-苄基吡咯烷-3-甲酸甲酯
参考文献:通过β-和γ-氨基酸的自由基脱羧合成官能化氮杂环
标题:通过β-和γ-氨基酸的自由基脱羧合成官能化氮杂环
摘要:通过β-和γ-氨基酸的自由基脱羧获得碘化或氧化氮杂环.这种温和,通用的反应可用于合成生物活性产品,如 4-芳基哌啶,羟基化哌啶和新型抗真菌剂.
Doi:10.1002/ejoc.200400698

专利信息

专利号:US-8252930-B2
优先权日:2006-07-06
标 题:Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition
发明人：STOIT AXEL; COOLEN HEIN K A C; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
权利人:STOIT AXEL; COOLEN HEIN K A C; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Azaindole derivatives of formula (I): n nwherein the symbols have the meanings given in the specification, are described. These compounds have a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition. The invention also relates to pharmaceutical compositions containing these compounds, to methods for preparing them, methods for preparing novel intermediates useful for their synthesis, methods for preparing compositions, and uses of such compounds and compositions, for example, their use in administering them to patients to achieve a therapeutic effect in disorders in which nicotinic receptors and/or dopamine transporters are involved, or that can be treated via manipulation of those receptors.

专利号:EP-2041131-B1
优先权日:2006-07-06
标 题 :Azaindole derivatives with a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition
发明人：STOIT AXEL; COOLEN HEIN K A C; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
权利人:ABBOTT HEALTHCARE PRODUCTS BV
摘要:The invention concerns azaindole derivatives having the general formula (I) wherein the symbols have the meanings given in the specification. These compounds have a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition. The invention also relates to pharmaceutical compositions containing these compounds, to methods for preparing them, methods for preparing novel intermediates useful for their synthesis, methods for preparing compositions, and uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in disorders in which nicotinic receptors and/or dopamine transporters are involved, or that can be treated via manipulation of those receptors.