专利号:US-7517828-B2 优先权日:2003-04-25 标 题 :Chiral broensted acid catalyst for asymmetric synthesis and method of asymmetric synthesis with the catalyst 发明人:AKIYAMA TAKAHIKO 权利人:TOAGOSEI CO LTD 摘要:A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.
专利号:US-11643503-B2 优先权日:2020-07-10 标题 :Highly spherical polyamide microparticles and synthesis methods related thereto 发明人:JAMALI HOJJAT SEYED 权利人:XEROX CORP 摘要:A method of synthesizing polyamide microparticles may comprise: dehydrating and shearing a mixture comprising a matrix fluid, an emulsion stabilizer at about 0.01 wt % to about 50 wt % based on the weight of the matrix fluid, a solvent at about 13 wt % to about 75 wt % based on the weight of the matrix fluid, and a cyclic amide monomer at about 20 wt % to about 90 wt % based on the weight of the matrix fluid to yield an emulsion having a water content of about 1 wt % or less based on the total weight of the emulsion; adding a deprotonating agent to the emulsion at a concentration of about 0.01 wt % to about 1 wt % based on the weight of the matrix fluid; and contacting the emulsion with a polymerization initiator under conditions effective to polymerize the cyclic amide monomer into a plurality of polyamide microparticles.
专利号:US-7754188-B2 优先权日:2003-06-30 标 题:Radiolabeled cannabinoid-1 receptor modulators 发明人:BURNS H DONALD; CHEN ALEX M; GIBSON RAYMOND E; GOULET MARK T; HAGMANN WILLIAM K; HAMILL TERENCE G; JEWELL JAMES P; LIN LINUS S; LIU PING; PERESYPKIN ANDREY V 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.
专利号:US-6852711-B2 优先权日:1998-09-11 标题:HIV protease inhibitors 发明人:BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:AGOURON PHARMA 摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
专利号:US-2006276329-A1 优先权日:2003-04-25 标题:Asymmetric synthesis catalyst based on chiral brsnsted acid and method of asymmetric synthesis with the catalyst
专利号:EP-1623971-A1 优先权日:2003-04-25 标 题:Asymmetric-synthesis catalyst based on chiral broensted acid and method of asymmetric synthesis with the catalyst
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合成参考文献
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 51. 摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 420. 摘要:Ciszek, B.; Fleischer, I., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 164.