CAS: 1428-95-1; 3-Amino-5-(Azepan-1-yl)-N-Carbamimidoyl-6-Chloropyrazine-2-Carboxamide

该化合物是属于氨基衍生物类别的合成化合物,其特征是结构特征,包括六甲基链和氨基酸混合物,有助于其生物活动,该化合物主要因其作为钾分解二酸剂的作用而得到承认,其作用是抑制肾管管内内上皮的钠渠道,从而在保存钾的同时促进钠排泄;六甲基氨基甲酸在水中表现出中等溶性,通常在标准实验室条件下保持稳定;其药理特性使其对与高血压和液体平衡失调有关的研究感兴趣;此外,该化合物与各种生物系统的互动突出其潜在的治疗用途,尽管有必要进一步研究以充分阐明其功效和安全特征;与许多化学物质一样,适当的处理和安全防范措施对于其生物活动和对人类健康的潜在影响至关重要.

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3-氨基-5,6-二氯-N-(二氨基亚甲基)吡嗪-2-甲酰胺 N-(3-Amino-5,6-Dichloro-Pyrazine-2-Carbonyl)-Guanidine 76599-75-2

合成工艺路线路线简述

    📜环己亚胺,3-氨基-5,6-二氯-N-(二氨基亚甲基)吡嗪-2-甲酰胺置于三乙胺体系中,用 二甲基亚砜 用作溶剂,化学反应生成阿米洛利
    参考文献:Amiloride Derived Inhibitors Of Acid-Sensing Ion Channel-3 (Asic3)
    标题:Amiloride Derived Inhibitors Of Acid-Sensing Ion Channel-3 (Asic3)
    摘要:A Series Of Amiloride Derivatives Modified At The 5-Position Of The Pyrazine Ring Were Evaluated As Inhibitors Of Acid-Sensing Ion Channel-3 (Asic3),A Novel Target For The Treatment Of Chronic Pain. (C) 2009 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2009.03.029

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    专利信息


    专利号:US-11872245-B2
    优先权日:2015-07-24
    标 题:Antiseptic polymer and synthesis thereof
    发明人：FATHI ALI; DEHGHANI FARIBA
    权利人:TRIMPH IP PTY LTD
    摘要:According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

    专利号:JP-6952348-B2
    优先权日:2015-07-24
    标题 :Sterilizing polymers and composites of polymers and cells and their synthesis

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    合成参考文献


    参考文献:10.1159/000174049
    摘要:Rebouças NA, Malnic G. Regulation of rat proximal tubule Na/H exchange by protein kinase C. Kidney Blood Press Res. 1996;19(2):87–93. doi: 10.1159/000174049.
    参考文献:10.1016/s0378-4274(99)00072-7
    摘要:García-Cañero R, Trilla C, Pérez de Diego J, Díaz-Gil JJ, Cobo JM. Na+ :H+ exchange inhibition induces intracellular acidosis and differentially impairs cell growth and viability of human and rat hepatocarcinoma cells. Toxicol Lett. 1999 Jun 01;106(2-3):215–28. doi: 10.1016/s0378-4274(99)00072-7.
    参考文献:10.1128/aac.48.6.2325-2330.2004
    摘要:Ewart GD, Nasr N, Naif H, Cox GB, Cunningham AL, Gage PW. Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages. Antimicrob Agents Chemother. 2004 Jun;48(6):2325–30. doi: 10.1128/aac.48.6.2325-2330.2004.
    参考文献:10.1006/abbi.1994.1048
    摘要:Wolf FI, Difrancesco A, Cittadini A. Characterization of Magnesium Efflux from Ehrlich Ascites Tumor Cells. Archives of Biochemistry and Biophysics. 1994 Feb;308(2):335–41. doi: 10.1006/abbi.1994.1048.
    参考文献:10.1097/00005344-199402000-00013|10.1097/00005344-199411000-00013
    摘要:Lai Z, Hotokebuchi N, Cragoe EJ, Nishi K. Effects of 5-(N, N Hexamethylene) Amiloride on Action Potentials, Intracellular Na, and pH of Guinea Pig Ventricular Muscle In Vitro. Journal of Cardiovascular Pharmacology. 1994 Nov;2(2):259–67. doi: 10.1097/00005344-199411000-00013.
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