CAS: 1210-56-6; 6-Methoxy-1-Methyl-1,2,3,4-Tetrahydro-β-Carboline

该化合物是一种在调节血液压力和体液平衡方面起着关键作用的激素,它来自肝脏合成的先质蛋白丙酰素的分泌,该激素主要在肾上皮质上作用,刺激aldosterone的分泌,促进肾脏的钠保留和钾排泄,从而影响血量和压力.Adrenoglomerutropropin也有血管抑制性,导致周边抗药性增加,血液压力进一步升高.其结构由氨基酸链组成,被归类为生物活性,该物质涉及各种生理过程,包括电解平衡和心血管功能的调节.对肾脏球素水平的调控,可以促成高血压和心脏衰竭等状况.了解其特性和机制对于针对心血管内核系统进行治疗战略至关重要.

英文名称6-Methoxy-1-Methyl-1,2,3,4-Tetrahydro-β-Carboline
中文名称6-甲氧基-1-甲基-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚
其它别名1-Methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline; 1-Methyl-6-methoxy-1,2,3,4-tetrahydro-b-carboline; 6-Methoxy-1,2,3,4-tetrahydroharman; 6-Methoxydihydroharmalan; 6-Methoxytetrahydroharman; ASH; Adrenoglomerulotropin; Aldosterone-stimulatinghormone; Dihydro-6-methoxyharmalan; MMTHC
CAS编号1210-56-6
FDA UNII编号:U18P8J9O2I
分子式:C13H16N2O分子量:216.28
产品CID: 282440
产品分类有机原料 → 生物碱及其衍生物 → 哈马拉生物碱

相似结构搜索
InChIKey: RDUORFDQRFHYBF-UHFFFAOYNA-N
1S/C13H16N2O/c1-8-13-10(5-6-14-8)11-7-9(16-2)3-4-12(11)15-13/h3-4,7-8,14-15H,5-6H2,1-2H3
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

MSDS等安全信息

上下游产品

Beta-Carboline, 1,2,3,4-Tetrahydro-1-Carboxy-6-Methoxy-1-Methyl- 29573-11-3
5-甲氧基色胺 2-(5-Methoxyindol-3-yl)Ethylamine 608-07-1

合成工艺路线路线简述

📜5-甲氧基色胺盐酸盐置于盐酸,甲醇,水体系中,化学反应 12.0H,反应生成6-甲氧基-1-甲基-2,3,4,9-四氢-1H-吡啶并[3,4-B]吲哚
参考文献:6-Hydroxy-And 6-Methoxy-β-Carbolines As Acetyl-And Butyrylcholinesterase Inhibitors
标题:6-Hydroxy-And 6-Methoxy-β-Carbolines As Acetyl-And Butyrylcholinesterase Inhibitors
摘要:In The Course Of Studies Directed Toward The Discovery Of Novel Acetyl-And Butyrylcholinesterase (Ache And Bche) Inhibitors For The Treatment Of Alzheimer'S Disease,We Focused On Beta-Carbolines (Bcs). 6-Oxygenated P-Carboline And P-Carbolinium Derivatives Based On The Serotonin Template Were Synthesized And Tested In Vitro For Their Ability To Inhibit Ache And Bche,Respectively. Particularly The Carbolinium Salts,Which Can Be Formed By Intracerebral Methylation Out Of The Tertiary-Bc Prodrugs,Show Inhibitory Activity Levels Reaching Those Of Galantamine,Physostigmine,And Rivastigmine. (C) 2006 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2006.08.067