CAS: 120-08-1; 6,7-Dimethoxy-2H-Chromen-2-One

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CAS号305-01-1 秦皮乙素 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号2033-89-8 3,4-二甲氧基苯酚 | CAS号15568-85-1 5-(甲氧亚甲基)-2,2-二... | CAS号73490-50-3 Z-4,5-dimethoxy... | CAS号109300-68-7 2-(4,5-dimethox... | CAS号14382-91-3 2-羟基-4,5-二甲氧基苯甲醛 | CAS号1099-45-2 乙基(三苯基膦)乙酸酯 | CAS号92-61-5 东莨菪内酯； 莨菪亭 | CAS号24160-53-0 2,4,5-三甲氧基肉桂酸 | CAS号114515-53-6 3-(2-hydroxy-4,... | CAS号56680-28-5 6,7-dimethoxy-3... | CAS号581-31-7 软木花椒素

📜2-碘-4,5-二甲氧基苯甲醛置于copper(I) Oxide,2-吡啶甲醛肟,Cesium Hydroxide Monohydrate,四丁基溴化铵体系中,化学反应 10.25H,反应生成6,7-二甲氧基香豆素
参考文献:六种 3,4-未取代香豆素的全合成.
标题:六种 3,4-未取代香豆素的全合成.
摘要:在本文中,我们描述了一种从市售原料中全合成 3,4-未取代香豆素的新方法.制备了六个实施例,包括五种天然存在的香豆素--7-羟基-6,8-二甲氧基-香豆素(isofraxidin),7-羟基-6-甲氧基香豆素(东莨菪碱),6,7,8-三甲氧基香豆素,6,7-二甲氧基香豆素(scoparone)和7,8-二羟基香豆素(瑞香素)和一种合成香豆素,7-羟基-6-乙氧基香豆素.此外,还得到了五种重要的邻羟基苯甲醛中间体,即2,4-二羟基-3,5-二甲氧基苯甲醛,2,4-二羟基-5-甲氧基苯甲醛,5-乙氧基-2,4-二羟基-苯甲醛,2-羟基苯甲醛-3,4,5-三甲氧基苯甲醛和2-羟基-4,5-二甲氧基苯甲醛.本文开发的方法只涉及三到四个步骤,可以以极好的收率快速合成这些重要分子.这是 6,7,8-三甲氧基香豆素和 7-羟基-6-乙氧基香豆素的首次合成.
Doi:10.3390/molecules181215613

专利信息

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-11986886-B2
优先权日:2019-06-06
标题:Rapid synthesis of metal nanoparticles
发明人：LEE KYUWAN; SINGER ROBERT H
权利人:ALBERT EINSTEIN COLLEGE MEDICINE
摘要:Described herein is a method of making a reduced metal nanoparticle, the method including mixing a reactive reducing agent with a metal salt in a solution at a temperature of 4-100° C., and forming the reduced metal nanoparticles in the solution. Also described is a kit including a reactive reducing agent that is sensitive to ßgalactosidase, a metal salt, and optionally a modifying agent/functionalizing agent for reduced metal nanoparticles. A 3,4-cyclohexeneoesculetin-B-D-galacto pyranoside (SGNP) gold nanoparticle and its use for measuring ßgalactosidase enzyme activity, comprising by detecting a structural change in the SGNPs caused by the ßgalactosidase are described. Further described are a point of care device, a chip, a biosensor, a laboratory animal, a gene delivery agent, a drug delivery agent, a diagnostic agent, or a disease targeting agent including SGNPs.

专利号:WO-2015160321-A1
优先权日:2014-04-18
标题 :Chromene analogs and use thereof in the treatment of cancer
发明人：OSMAN NÄ°DAÄ° ÖZEÅž
权利人:OSMAN NÄ°DAÄ° ÖZEÅž
摘要:The present invention is about 8 different molecules, created from Chromene-2-one, their derivatives and pharmaceutical compositions containing these compounds. In generated 8 different molecule Rl and R2 positions were chosen as site of modifications, and these sites will be methyl (-CH3), ethyl (- C2H5), hydroxy! (-OH) and their combinations with one another. The compounds mentioned in this application have a potential to inhibit growth of various cancer cells, activate caspases and induce ceil death and prevent formation of new blood vessels by inhibiting synthesis of vascular endothelial cell growth factor (VEGF). Therefore, compounds mentioned in this application can be used to treat pancreas cancer, prostate cancer, skin cancer, ovarian cancer, bladder cancer, liver cancer, breast cancer, small-and non-smal-celi lung cancer, brain cancer, neuroblastoma, glioblastoma, cervical cancer, endometrial cancer, head and neck cancer, bone cancer, kidney cancer, thyroid cancer, osefagus cancer, lymphoma, sarcomas, cancers of general Gl track, stomach cancer, duodenum cancer, small intestine cancer, colon cancer, anal cancer, and types of leukemia.

专利号:WO-2023156270-A1
优先权日:2022-02-18
标题:Coumarin synthesis and uses thereof
发明人：CONRATH UWE; LANGENBACH CASPAR; BEYER SEBASTIAN FELIX; SCHWINGES PATRICK; SCHULTHEISS HOLGER; BEESLEY ALEXANDER; LINKE CEDRIC
权利人:BASF SE; RWTH AACHEN
摘要:The present invention relates to genes, materials and methods for coumarin synthesis and the application thereof for improving plant health, preferably against infection by phythopathogenic microorganisms, and/or for improving plant health against coumarin-induced adverse effects on plant health. Furthermore, the invention pertains to methods and uses of such genes and mate- rials for creating correspondingly beneficial plant cells, plant parts and whole plants, and relates to products obtained from such plants or plant parts.

专利号:US-2010324266-A1
优先权日:2000-09-11
标题:Photocleavable Protecting Groups
发明人：BARONE ANTHONY D; MCGALL GLENN H
权利人:AFFYMETRIX INC
摘要:Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Y, wherein Y is a chemical structure as shown in FIG. 1 . Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.