CAS: 85692-37-1; 1-(1-Methyl-1H-Imidazol-2-yl)Ethanone

该化合物是一个有机化合物,其特征是其imidazole环结构,有助于其独特的化学特性;该化合物的特性是配以替代的imidazole的氯酮功能组,特别是乙酮单体;该甲基组在imidazole环上的存在加强了其稳定性和再活动;这种性质的化合物通常由于甲酮和氮原子存在于甲状腺中而呈现中度极性,可参与氢的结合;这种物质可能在不同领域,包括制药和材料科学中引起兴趣,因为其生物活动潜力和作为合成化学的建筑块的能力,其溶性特征可能受到现有功能组的影响,使其在极溶剂中溶解.在处理和储存时,应参考安全数据,因为与任何化学物质一样,确保采取适当的预防措施.

结构式图片

相似化合物

13750-81-7 30148-23-3 41507-36-2

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

1-甲基-1H-咪唑-2-甲醛 N-Methyl-2-Imidazolcarboxaldehyde 13750-81-7
1-(1-Methyl-1H-Imidazol-2-yl)Ethanol 41507-36-2
2-乙酰基咪唑 1-(1H-Imidazol-2-yl)Ethanone 53981-69-4

合成工艺路线路线简述

  • 1696-20-4 + 616-47-7 = 85692-37-1
    反应条件:1.1 Solvents: Tetrahydrofuran; Rt -> -78 °C1.2 Rt -> 0 °C1.3 Reagents: Butyllithium Solvents: Hexane; 5 Min,0 °C; 10 Min,0 °C1.4 15 Min,-78 °C; 1 H,-78 °C; 15 Min1.5 Reagents: Hydrochloric Acid Solvents: Water; 5 Min
    标题:Catalytic Conjugate Additions Of Carbonyl Anions Under Neutral Aqueous Conditions
    作者:Myers,Michael C.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2005 卷标:127(42) 页码:14675-14680]

    1696-20-4 + 616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; Rt -> 0 °C; 5 Min,0 °C; 10 Min,0 °C1.2 Solvents: Tetrahydrofuran; 15 Min,-78 °C; 1 H,-78 °C; 15 Min,-78 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 5 Min,Rt
    标题:Dual Heterogeneous Catalysis For A Regioselective Three- Component Synthesis Of Bi- And Tri(Hetero)Arylpyridines
    作者:Allais,Christophe; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2012 卷标:354(13) 页码:2537-2544]

    127-19-5 + 616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C; 15 Min,-78 °C1.2 Rt
    标题:Organic Light Emitting Diode Containing Ir Complex Having A Novel Ligand As A Phosphorescent Emitter
    参考文献:Taiwan]

    78191-00-1 + 616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 10 Min,-78 °C; 2 H,-78 °C1.2 Solvents: Tetrahydrofuran; 2 H,-78 °C; -78 °C -> Rt1.3 Reagents: Water
    标题:Fe-Bpsalan Complex-Catalyzed Asymmetric 1,3-Dipolar [3 + 2] Cycloaddition Reaction Of N,N'-Cyclic Azomethine Imines With α,β-Unsaturated Acyl Imidazoles
    作者:Lu,Hao; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2023 卷标:10(8) 页码:2054-2060]

    616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 30 Min,Rt; Rt -> -78 °C1.2 3 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water; Rt
    标题:Strategy For Catalytic Chemoselective Cross-Enolate Coupling Reaction Via A Transient Homocoupling Dimer
    作者:Tanaka,Takafumi; Et Al
    参考文献:Organic Letters 日期:2018 卷标:20(12) 页码:3541-3544]

    51081-36-8 = 85692-37-1 [标题:Reaction Conditions
    标题:N-Methylimidazole
    作者:Tindall,Craig; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2014 卷标:1 页码:1-13]

    616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C2.1 -
    标题:N-Methylimidazole
    作者:Tindall,Craig; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2014 卷标:1 页码:1-13]

    127-19-5 + 616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -60 °C
    标题:Design And Application Of A Low-Temperature Continuous Flow Chemistry Platform
    作者:Newby,James A.; Et Al
    参考文献:Organic Process Research & Development 日期:2014 卷标:18(10) 页码:1211-1220]

    78191-00-1 + 616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 20 Min,-78 °C; 30 Min,-78 °C1.2 Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C; -78 °C -> Rt1.3 Reagents: Sodium Bicarbonate,Sodium Chloride,Water
    标题:Fe-Bpsalan Complex-Catalyzed Asymmetric [4 + 2] Cycloaddition Of Cyclopentadiene With α,β-Unsaturated Heterocycles
    作者:Chen,Kai-Ge; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(13) 页码:8289-8302]

    616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C; -78 °C -> Rt; 30 Min,Rt; Rt -> -78 °C1.2 -78 °C; -78 °C -> Rt; 3 H,Rt
    标题:A One-Pot Oxidation/enantioselective Oxa-Michael Cascade
    作者:Willemsen,Jorgen S.; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(14) 页码:2892-2898]

    616-47-7 = 85692-37-1
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C; 30 Min,-78 °C -> Rt; Rt -> -78 °C1.2 -78 °C; -78 °C -> Rt
    标题:Diastereoselective Trapping Of Transient Carboxylic Oxonium Ylides With α,β-Unsaturated 2-Acyl Imidazoles
    作者:Zhang,Mengchu; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2020 卷标:362(21) 页码:4662-4667]

    51081-36-8 = 85692-37-1
    反应条件:1.1 Solvents: Diethyl Ether1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Synthesis,Characterization,And Reactivity Of 1-(1-Methylimidazol-2-Yl)Ethenes
    作者:Abarca-Gonzalez,Belen; Et Al
    参考文献:Synthetic Communications 日期:1990 卷标:20(3) 页码:321-31]

    84547-59-1 = 85692-37-1 [标题:Reaction Conditions
    标题:Substituent Effects On Carbon-13 Chemical Shifts Of Aromatic Carbons In β-O-4 And β-5 Type Lignin Model Compounds
    作者:Hassi,H. Y.; Et Al
    参考文献:Journal Of Wood Chemistry And Technology 日期:1987 卷标:7(4) 页码:555-81]

    84547-59-1 = 85692-37-1 [标题:Reaction Conditions
    标题:Hydrogenation Sequence Of Acetophenone On Commercial Platinum Catalyst Ap-64
    作者:Smirnova,N. A.; Et Al
    参考文献:Azerbaidzhanskii Khimicheskii Zhurnal 日期:1987 卷标:(2) 页码:19-23
📜1-甲基-1H-咪唑-2-甲醛置于manganese(Iv) Oxide体系中,用 乙醚,正己烷,氯仿 作为反应溶剂,化学反应 7.0H,反应生成 1-(1-甲基-1H-咪唑-2-基)乙酮
参考文献:取代的2-(1-甲基-2-咪唑基)喹啉的合成
标题:取代的2-(1-甲基-2-咪唑基)喹啉的合成
摘要:甲基锂与1-甲基1-2-咪唑甲醛的反应得到相应的醇2.用二氧化锰氧化化合物2得到2-乙酰基1-1-甲基咪唑(3).使用化合物3和取代的靛红4,制备了相应的喹啉-4-羧酸(5).5的酸咪唑化物与适当的胺反应反应生成酰胺6.通过库尔修斯重排以高收率制备氨基甲酸酯10.取代的喹啉-4-胺13通过化合物的酸水解而获得的10(r 1 =吨-Bu).胺13与二烷基氨基烷基氯的烷基化得到化合物14.
DOI:10.1002/jhet.5570340526

海关参考信息

专利信息


专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:EP-3305900-A1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

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合成参考文献


参考文献:10.1055/s-2007-992386
摘要:Sibi M, Yang Y. Chiral Lewis Acid Catalyzed Enantioselective Conjugate Radical Additions to α,β-Unsaturated 2-Pyridyl Ketones. Synlett. 2008 Jan;2008(1):83–8. doi: 10.1055/s-2007-992386.
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