CAS: 79794-75-5; Ethyl 4-(8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11-Ylidene)Piperidine-1-Carboxylate

上下游产品

CAS号541-41-3 氯甲酸乙酯 | CAS号38092-89-6 甲基氯雷他定 | CAS号7087-68-5 N,N-二异丙基乙胺 | CAS号32998-95-1 3-甲基-吡啶-2-羧酸叔丁酰胺 | CAS号31255-57-9 3-[2-(3-氯苯基)乙基]... | CAS号107285-30-3 3-[2-(3-CHLORO-... | CAS号63463-36-5 magnesium,1-met... | CAS号7440-44-0 活性炭 | CAS号20970-75-6 2-氰基-3-甲基吡啶 | CAS号119770-60-4 (1-甲基-4-哌啶基)[3-... | CAS号100643-71-8 地氯雷他定 | CAS号117796-52-8 N-乙酰去氯雷他定

2-氰基-3-甲基吡啶置于正丁基锂,硫酸,碘,硼酸,Magnesium,三乙胺,三氯氧磷体系中,用 四氢呋喃,1,2-二溴乙烷,氯苯,甲苯 作为反应溶剂,化学反应 40.83H,反应生成 氯雷他定
参考文献:一种氯雷他定的制备方法
标题:一种氯雷他定的制备方法
摘要:本发明提供了一种氯雷他定的制备方法.本发明方法是以2‑氰基‑3‑甲基吡啶为原料,经ritter反应,间氯氯苄缩合,Pocl3脱保护基,格式反应,环合,氯甲酸乙酯取代后得到4‑(8‑氯‑5,6‑二氢‑11H‑苯并[5,6]环庚烷并[1,2‑b]吡啶‑11‑亚基)‑1‑哌啶羧酸乙酯.本发明通过革新后处理工艺,采用新的环合体系催化反应,避免使用成本高毒性大的强酸,为工业生产提供一种更加温和,经济的合成方法.

专利信息

专利号:US-6608202-B1
优先权日:2001-08-21
标题:Process of synthesis of a tricyclic ketone intermediate
发明人：DORAN HENRY J; O'NEILL PAT M; WILLIAMS ROBERT P
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen,and intermediates therefor from easily available starting materials by a simple route.

专利号:US-10155665-B2
优先权日:2014-11-03
标题 :Zeolite synthesis with dominant and secondary templates
发明人：LAI WENYIH FRANK; ROLLMAN NICHOLAS S; WALP JENNA L; LONERGAN WILLIAM W
权利人:LAI WENYIH FRANK; ROLLMAN NICHOLAS S; WALP JENNA L; LONERGAN WILLIAM W; EXXONMOBIL RES & ENG CO
摘要:Methods are provided for synthesis of various types of zeolites using synthesis mixtures that contain a dominant structure directing agent and one or more secondary structure directing agents. Advantageously, the secondary structure directing agents may substantially not alter the crystal structure and/or morphology of the crystals generated by a synthesis mixture in the presence of the dominant structure directing agent.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-5296208-A
优先权日:1992-08-07
标 题 :Molecular sieve synthesis
发明人：LESCH DAVID A
权利人:UOP INC
摘要:In the hydrothermal synthesis of crystalline microporous molecular sieves from a reaction system containing an organic templating agent, it is found that removal of at least some of the organic reagent prior to the time the formation of crystalline product is complete results in an increased yield of the product. The removal of the organic reagent disrupts the equilibrium that is normally established in the reaction system at the selected crystallization temperature between product formation and product dissolution and shifts the reaction toward the formation of additional product before a new equilibrium can form.

专利号:US-9433935-B2
优先权日:2014-03-28
标 题 :Synthesis of framework modified ZSM-48 crystals
发明人：LAI WENYIH FRANK; ZHANG LEI
权利人:LAI WENYIH FRANK; ZHANG LEI; EXXONMOBIL RES & ENG CO
摘要:Methods are provided for synthesis ZSM-48 crystals (or other MRE framework crystals) having heteroatoms different from silicon and aluminum incorporated into the framework structure, and use of such crystals for applications such as catalytic processing of hydrocarbonaceous feeds. Examples of heteroatoms can include titanium, zirconium, and zinc.

专利号:US-5493065-A
优先权日:1993-06-16
标题:Liquid phase ethylbenzene synthesis with MCM-49
发明人：CHENG JANE C; SMITH C MORRIS; WALSH DENNIS E
权利人:MOBIL OIL CORP
摘要:There is provided a process for the liquid phase synthesis of ethylbenzene with a zeolite designated MCM-49. The process involves the alkylation of benzene with ethylene under liquid phase conditions.