专利号:US-7786259-B2 优先权日:2001-05-23 标题:Attachment and elaboration strategies for inverse peptide synthesis 发明人:GUTHEIL WILLIAM G 权利人:UNIV MISSOURI 摘要:The present invention provides a process for preparing an immobilized peptide derivative of formula (Vb): n ncomprising reacting a functionalized solid support comprising Sub-L wherein Sub is a solid support and L is a cleavable linker, with H—[NH—A—C(O)]—O(tBu), then reacting the immobilized product with compound of the formula RHN—A—C(O)OH, wherein the RHN—A—C(O) group is the residue of a N-protected α-amino acid, in the presence of a coupling agent, to yield an immobilized peptide derivative of the formula (Vb).
专利号:US-9890111-B2 优先权日:2008-07-21 标题 :Crystal structure of bifunctional transglycosylase PBP1b from E. coli and inhibitors thereof 发明人:WONG CHI HUEY; MA CHE ALEX; CHENG TING JEN RACHEL; CHENG WEI CHIEH 权利人:ACADEMIA SINICA 摘要:The crystal structure at 2.16 â„« resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from Escherichia coli , in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor-binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBP1b are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.
专利号:CN-109810062-B 优先权日:2019-01-24 标题:Phenylimidazole derivative, synthesis method thereof and application of phenylimidazole derivative in pesticide
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合成参考文献
摘要:Fogel, M. S.; Shellnutt, Z. S.; Koide, K., Science of Synthesis: Dearomatizations, (2026) .