3-异氰酸丙烯置于lithium Aluminium Tetrahydride,乙醚体系中,化学反应生成 N-甲基烯丙基胺 参考文献:The Reduction Of Isocyanates And Isothiocyanates With Lithium Aluminum Hydride 标题:The Reduction Of Isocyanates And Isothiocyanates With Lithium Aluminum Hydride 摘要: DOI:10.1021/jo50016A012
专利号:US-9688644-B2 优先权日:2009-04-30 标 题 :Synthesis of Tetracyclines and intermediates thereto 发明人:MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.
专利号:US-12180182-B2 优先权日:2021-12-01 标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same 发明人:DAI MINGJI 权利人:PURDUE RESEARCH FOUNDATION 摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.
专利号:US-3888844-A 优先权日:1971-09-10 标 题:Halogenated esters of phosphorus-containing acids (ii) 发明人:D ALELIO GAETANO F 权利人:ALELIO GAETANO F D 摘要:This invention deals with new phosphorus containing polymeric esters having pendent groups therein of the formula OBTAINED BY THE REACTION OF A POLYMER HAVING AT LEAST 2 AND PREFERABLY AT LEAST 4 HYDROXY GROUPS THEREIN WITH A PHOSPHORUSHALOGEN COMPOUND OF THE FORMULA XP(O) (ORCX CXR'')2 wherein: R represents a divalent hydrocarbon radical containing 1-20 carbon atoms; R'' represents X, hydrogen or R''''; R'''' represents a monovalent hydrocarbon radical containing 1-20 carbon atoms; and X represents chlorine or bromine. Somewhat related polymers are also disclosed as derived by the reaction of WHEREIN Q'' is an organic moiety, n'' has a value of at least one, n'''' is one or two, R'''''' represents hydrogen or a monovalent hydrocarbon group of 1-20 carbon atoms, and the other symbols have the same meaning as defined above. Also disclosed are the reaction products of the phosphite compound HOP(ORCX CXR'')2 with an aldehyde and an organic nitrogen compound having one or two hydrogen atoms on the nitrogen, or with a compound having an ethylenic group therein. These new ester polymers and compounds are useful particularly as fire retardants, agricultural chemicals, fuel additives, plasticizers, monomers and intermediates for the synthesis of other useful derivatives.
专利号:US-3862978-A 优先权日:1967-08-24 标 题:Catalytic synthesis of organic halogen compounds from an ethylenically unsaturated compound and a halogenated organic compound 发明人:DECKER DALTON L; MOORE CARL; TOUSIGNANT WILLIAM F 权利人:DOW CHEMICAL CO 摘要:Method for forming a chemical adduct of an ethylenically unsaturated compound with a halogenated organic compound having on a single carbon atom thereof at least two halogen atoms at least one of which is chlorine, bromine or iodine, characterized by employing a catalyst of which the essential members are copper and an amine selected from piperidine, substituted piperidines, cyclohexylamines and secondary amines on which the hydrocarbyl substituents are allyl, benzyl or lower alkyl radicals.
专利号:EP-0379423-B1 优先权日:1989-01-16 标题:Process for the preparation of phenylpropionic acid 摘要:The invention relates to the field of organic chemistry, and more specifically to the synthesis of phenylpropionic acids. Its specific subject is a new process for the preparation of 2-[4-(R-amino)phenyl]propionic acids of general formula I which consists in subjecting a 2-(4-aminophenyl)propionic derivative of formula II in which R1 is hydrogen or a C1-C6 alkyl radical, to the action of an alkylating agent in a heterogeneous phase in the presence of a phase transfer catalyst and a basic agent in an aqueous medium. The acids obtained are active principles of medicaments.
专利号:US-7102032-B2 优先权日:2003-04-24 标 题 :Purification of amide compound 发明人:SAKANO YASUNORI; KOIKE NORIYUKI 权利人:SHINETSU CHEMICAL CO 摘要:In the synthesis of an amide compound through reaction of an acyl fluoride group-bearing compound with an amino compound, a reaction mixture contains the amide compound and hydrogen fluoride or a hydrofluoric acid amine salt. The amide compound is recovered in high purity form by adding an oxide, carbonate or hydroxide of an alkaline earth metal to the reaction mixture to convert the hydrogen fluoride or hydrofluoric acid amine salt to an alkaline earth metal fluoride salt that can be readily removed by filtration.
参考标题:Synthesis Of Sulfonimidamides From Sulfenamides Via An Alkoxy‐amino‐λ 6 ‐sulfanenitrile Intermediate 作者:Edward L. Briggs,Arianna Tota,Marco Colella,Leonardo Degennaro,Renzo Luisi,James A. Bull |发布日期:2019.10 摘要:Few Operationally Simple Methods For Their Preparation. Here, The Synthesis Of Nh-Sulfonimidamides Is Achieved Directly From Sulfenamides, Themselves Readily Formed In One Step From Amines And Disulfides. A Highly Chemoselective And One-Pot Nh And O Transfer Is Developed, Mediated By Phio In Iproh, Using Ammonium Carbamate As The Nh Source, And In The Presence Of 1 Equivalent Of Acetic Acid. A Wide
合成参考文献
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