CAS: 612-13-5; 2-(Chloromethyl)Benzonitrile

上下游产品

CAS号529-19-1 邻甲基苯腈 | CAS号118-90-1 邻甲基苯甲酸 | CAS号7782-50-5 氯气 | CAS号5388-42-1 2-苯基-1-氧代二氢氮杂茚 | CAS号3759-28-2 2-氰基苯乙腈 | CAS号195067-13-1 (9ci)-3-氨基-1H-茚... | CAS号87-41-2 苯酞 | CAS号83-33-0 1-茚酮 | CAS号550-44-7 N-甲基邻苯二甲酰亚胺 | CAS号304-19-8 1H-Isoindole-1,... | CAS号23973-65-1 2-(diethoxyphos... | CAS号776-79-4 3-(2-羧基苯基)丙酸 | CAS号612-35-1 2-苄基苯甲酸

邻甲基苯腈置于次氯酸叔丁酯,(Phenanthroline)2Agotf体系中,用 乙腈 作为反应溶剂,化学反应 48.0H,以42%的收率获得产物邻氰基氯苄
参考文献:银催化的c(sp 3)-h氯化
标题:银催化的c(sp 3)-h氯化
摘要:开发了银催化的苄基,叔和仲c(sp 3)-H键的氯化反应.反应在室温下在空气气氛下以低至0.2Mol%的催化剂负载量进行,具有合成上有用的官能团相容性.区域选择性和反应性趋势表明氯化是通过自由基途径进行的,但是不能排除中间的烷基银物种.
DOI:10.1021/acs.Orglett.7B00367

专利信息

专利号:WO-2015092739-A1
优先权日:2013-12-19
标题:Process for preparation of alogliptin
发明人：VADALI LAKSHMANA RAO; DASARI SRINIVASA RAO; MANUKONDA SESHADRI RAO; PONDURI RAJASEKHAR
权利人:MYLAN LAB LTD
摘要:Processes for the preparation of alogliptin benzoate are disclosed. The present disclosure also provides intermediates useful in the synthesis of alogliptin benzoate.

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