CAS: 5622-77-5; O-Butylhydroxylamine

该化合物是一种含有化学配方C4H11NO的氢氧胺衍生物.它通常用作有机合成的多用途中间体,特别是用于制备氧化氮,氢氧酸和其他含氮化合物.丁基化合物增加了其在有机溶剂中的溶解性,便利了非水介质的反应.该化合物因其在制药和农用化学应用中的作用而备受珍视,它作为活性成分的建筑块.在受控条件下的稳定性和碳基化合物的再活性使研究人员和工业化学家作出实际选择.适当的处理由于其对氧化和水分的潜在敏感性而至关重要.

结构式图片

MSDS等安全信息

    上下游产品

    CAS号51951-28-1 2-butoxyisoindo... | CAS号23362-50-7 N-benzoyl-O-but... | CAS号2372-45-4 正丁醇钠 | CAS号38483-44-2 butoxy-carbamic... | CAS号109-65-9 正溴丁烷 | CAS号778-28-9 对甲苯磺酸正丁酯 | CAS号7647-01-0 盐酸 | CAS号26889-18-9 N-butoxy-benzim... | CAS号91536-42-4 N-butoxyacetamide | CAS号4490-82-8 O-丁基羟胺盐酸盐 | CAS号52883-25-7 Urea, N-butoxy | CAS号38128-83-5 nci 143-474

    合成工艺路线路线简述

    • 合成目标产物 Aminooxy-N-Butane Hydrochloride 主要起始原料 1H-Isoindole-1,3(2H)-Dione, 2-Butoxy-
    • (文献来源)合成步骤主要原料 1H-Isoindole-1,3(2H)-Dione, 2-Butoxy-
    📜Sodium Butanolate置于氯胺,乙醚,正丁醇体系中,化学反应生成 O-丁基羟胺
    参考文献:Theilacker; Ebke,Angewandte Chemie,1956,Vol. 68,P. 303
    标题:Theilacker; Ebke,Angewandte Chemie,1956,Vol. 68,P. 303

    海关参考信息

    专利信息


    专利号:US-9353057-B2
    优先权日:2003-12-30
    标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    发明人:GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
    权利人:XENOPORT INC
    摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

    专利号:US-10717718-B2
    优先权日:2015-11-17
    标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3
    发明人:VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE
    权利人:CENTRE NAT RECH SCIENT
    摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .

    专利号:US-12006540-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
    发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
    权利人:UNIV COLUMBIA
    摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

    专利号:US-8017776-B2
    优先权日:2003-07-15
    标题 :Methods for synthesis of acyloxyalkyl compounds
    发明人:BHAT LAXMINARAYAN; GALLOP MARK A
    权利人:XENOPORT INC
    摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

    专利号:US-2015158809-A9
    优先权日:2013-02-26
    标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
    发明人:WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
    权利人:XENOPORT INC
    摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

    专利号:WO-2023225524-A1
    优先权日:2022-05-17
    标题:Preparation of highly concentrated mrna
    发明人:GENG MARK; SINOIMERI JAMES
    权利人:MODERNATX INC
    摘要:Provided herein are compositions of highly concentrated mRNA and related methods for preparation and use of the compositions as mRNA process intermediates in the synthesis of therapeutic and prophylactic mRNA formulations.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1016/j.jneuroim.2004.03.001
    摘要:Takahashi HK, Iwagaki H, Mori S, Yoshino T, Tanaka N, Nishibori M. Beta 2-adrenergic receptor agonist induces IL-18 production without IL-12 production. J Neuroimmunol. 2004 Jun;151(1-2):137–47. doi: 10.1016/j.jneuroim.2004.03.001.
    参考文献:10.1016/j.ejphar.2004.03.039
    摘要:Koike K, Yamashita Y, Horinouchi T, Yamaki F, Tanaka Y. cAMP-independent mechanism is significantly involved in beta2-adrenoceptor-mediated tracheal relaxation. Eur J Pharmacol. 2004 May 10;492(1):65–70. doi: 10.1016/j.ejphar.2004.03.039.
    摘要:Katoch SS, Garg A, Sharma S. Histological evidences of reparative and regenerative effects of beta-adrenoceptor agonists, clenbuterol and isoproterenol, in denervated rat skeletal muscle. Indian J Exp Biol. 2006 Jun;44(6):448–58.
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