CAS: 54711-38-5; 7-(Diethylamino)-4-(Hydroxymethyl)-2H-Chromen-2-One

该化合物是一种荧光可乐衍生物,由于具有很强的荧光素特性,在生物化学和分析应用中广泛使用.该化合物在4级具有氢氧甲基组的特点,加强了其与生物分子相融合的回活动,而7级的二乙基氨基替代成分有助于其溶血球行为和金枪鱼排放.这使得它作为荧光探测器或标志在实验,成像和传感器开发中具有价值.其高量产量和可光化性进一步确保了在苛刻环境中的可靠性能.该化合物在PH敏感研究和酶相关检测系统中特别有用,提供了准确和可复制的结果.

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上下游产品

7-diethylamino-4-methylcoumarin equatorial-[7-(diethylamino)coumarin-4-yl]methyl adenosine cyclic 3',5'-monophosphate axial-[7-(diethylamino)coumarin-4-yl]methyl adenosine cyclic 3',5'-monophosphate (7-N,N-diethylamin°Coumarin-4-yl)-methyl-N-(9-fluorenylmethyloxycarbonyl)aspartic acid 55H62N2O17C55H62N2O17 H-Asp(DEACM)-D-Phe-Lys(B°C)-Gly-OH

合成工艺路线路线简述

    📜(7-(Diethylamino)-2-Oxo-2H-Chromen-4-yl)Methyl Acetate置于fac-Tris(2-Phenylpyridinato-N,C2')Iridium(Iii),水体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.33H,以73.6%的收率获得产物7-(二乙基氨基)-4-(羟基甲基)-2H-苯并吡喃-2-酮
    参考文献: Photolytic Compounds And Triplet-Triplet Annihilation Mediated Photolysis[fr] Composés Photolytiques Et Photolyse Induite Par Annihilation Triplet-Triplet
    标题: Photolytic Compounds And Triplet-Triplet Annihilation Mediated Photolysis[fr] Composés Photolytiques Et Photolyse Induite Par Annihilation Triplet-Triplet
    摘要:这项发明提供了新型光解化合物和前药,纳米粒子及其组合物,以及通过三重-三重湮灭介导的光解方法.

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    专利信息


    专利号:US-2010324266-A1
    优先权日:2000-09-11
    标题:Photocleavable Protecting Groups
    发明人:BARONE ANTHONY D; MCGALL GLENN H
    权利人:AFFYMETRIX INC
    摘要:Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Y, wherein Y is a chemical structure as shown in FIG. 1 . Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.

    专利号:US-2011028350-A1
    优先权日:1995-12-15
    标题:Photocleavable protecting groups
    发明人:MCGALL GLENN H; BARONE ANTHONY D
    权利人:AFFYMETRIX INC
    摘要:Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Y, wherein Y is a chemical structure as shown in FIG. 5. Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.

    专利号:US-11725222-B2
    优先权日:2016-12-01
    标题:Cleavable nucleotide analogs and uses thereof
    发明人:GRISWOLD JR KETTNER JOHN FREDERICK; KOHMAN RICHARD E; CHURCH GEORGE M; RITTICHIER JONATHAN
    权利人:HARVARD COLLEGE
    摘要:Cleavable nucleotide analogs are provided. The nucleotide analog includes a nucleotide molecule attached to a cleavable moiety wherein the cleavable moiety comprises a protective group and/or a linker attached to a fluorophore. The cleavable moiety is linked to the oxygen atom of the 3′-OH of the pentose of the nucleotide molecule. The nucleotide analogs can be used in making polynucleotide molecules using template independent polymerases. The nucleotide analogs can act as reversible terminators during DNA sequencing by synthesis. The cleavage of the cleavable moiety restores a free 3′-OH functional group allowing growth of the polynucleotide molecule. The general structures as well as proposed synthetic schemes for the nucleotide analogs are also provided.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/acs.jmedchem.9b00688
    摘要:Li Z, Su K, Jiang Z, Yu Y, You Q, Zhang X. Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light. J Med Chem. 2019 Aug 22;62(16):7583–8. doi: 10.1021/acs.jmedchem.9b00688.
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