CAS: 527-20-8; Pentachloroaniline

该化合物是一种氯化芳烃,其分子式为C6HCl5NH2.该化合物的特点是氯化程度高,增强了其稳定性和降解抗力,主要用作合成农用化学品,染料和其他特殊化学品的中间体.五氯苯酚替代模式有助于其强大的电子脱色特性,使其在需要电益芳烃替代或作为进一步功能化的前体的反应中具有宝贵价值.由于其卤素含量高的结构,它在极地溶解剂中表现出低溶性,但在有机介质中溶解良好.妥善处理由于其潜在的毒性和环境持久性而至关重要.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

hexachlorobenzene Quintozene diethyl ether 3,5-Dichloroaniline2,3,4,6-Tetrachlor-5-amino-anisol pentachlorothiophenol Pentachlorophenol 2,3,4,5,6-pentachloroiodobenzene

合成工艺路线路线简述

    3,5-二氯苯胺置于四氯化碳体系中,化学反应生成 五氯苯胺
    参考文献:Goldschmidt; Strohmenger,Chemische Berichte,1922,Vol. 55,P. 2465
    标题:Goldschmidt; Strohmenger,Chemische Berichte,1922,Vol. 55,P. 2465

    海关参考信息

    专利信息


    专利号:US-4705866-A
    优先权日:1985-12-26
    标 题 :Synthesis of N-halogenated phenyl maleimide compounds with tin containing catalysts
    发明人:GASTINGER ROBERT G
    权利人:ATLANTIC RICHFIELD CO
    摘要:A process for the preparation of N-brominated or N-chlorinated phenylmaleimide by reacting maleic anhydride and a brominated or chlorinated aniline compound at temperatures of from about 100 DEG C. to about 210 DEG C. in the presence of tin containing catalyst compound and optionally an inert solvent.

    专利号:US-4477389-A
    优先权日:1982-10-25
    标 题 :Polyhalogenated phenyl isocyanate synthesis with excess phosgene and either triethylamine or tetramethylurea
    发明人:CHEN GEORGE C; ROWELL ROGER M
    权利人:US AGRICULTURE
    摘要:Two procedures are described that can be used to prepare polyhalogenated phenyl isocyanates (2,4,6-trichloro,2,3,5,6-tetrachloro, pentachloro, 2,4,6-tribromo and 2,4,6-trifluoro derivatives) from the corresponding anilines in good yields (95-99%) with small amounts of urea byproducts (1-5%) within reasonable reaction times (3-6 hours). These are: n 1. Liquid phase phosgenation of polyhalogenated anilines with tertiary amines as a hydrogen chloride acceptor. n 2. Liquid phase phosgenation of polyhalogenated anilines in excess phosgene at the beginning and throughout the reaction.

    专利号:CN-101234996-B
    优先权日:2008-02-29
    标题:A kind of green synthesis method of ketazine

    专利号:CN-1706817-A
    优先权日:2005-05-20
    标 题 :Synthesis process of methyl ethyl ketone azine
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Didem Okutman Tas, Et Al. Microbial Transformation Of Pentachloronitrobenzene Under Nitrate Reducing Conditions. Biodegradation. 2010 Sep;21(5):691-702.
    [参考文献]: Didem Okutman Tas, Et Al. Theoretical Investigation Of The Sequential Reductive Dechlorination Pathways Of Chlorobenzenes And Chloroanilines. Biotechnol Bioeng. 2010 Feb 15;105(3):574-87.
    [参考文献]: G L Larsen, Et Al. Intermediary Metabolism Of Pentachloronitrobenzene In The Control And Germ-Free Rat And Rat With Cannulated Bile Ducts. Xenobiotica. 1998 Oct;28(10):973-84.
    [参考文献]: Hsiao-Wei Wen, Et Al. Application Of Gamma Irradiation In Ginseng For Both Photodegradation Of Pesticide Pentachloronitrobenzene And Microbial Decontamination. J Hazard Mater. 2010 Apr 15;176(1-3):280-7.
    [参考文献]: J G Bruno, Et Al. In Vitro Selection Of Dna To Chloroaromatics Using Magnetic Microbead-Based Affinity Separation And Fluorescence Detection. Biochem Biophys Res Commun. 1997 May 8;234(1):117-20.

    合成参考文献


    摘要:Puylaert, P.; Savini, A.; Hinze, S., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 333.
    摘要:Journal of Agricultural and Food Chemistry., 15(654), 1967
    摘要:Adrian P et al; Toxicol Environ Chem: Vol 20-21 pp. 109-120 (1989)
    摘要:Sabljic A et al; Chemosphere 31: 4489-4514 (1995)
    摘要:Smelt JH; pp. 3-13 in Decomposition of Toxic and Nontoxic Organic Compounds in Soil, Overcash VR ed., Ann Arbor,MI: Ann Arbor Sci Publ (1981)
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