CAS: 5223-06-3; 2-(5-Ethylpyridin-2-yl)Ethanol

相似化合物

100189-17-1 103-74-2 860410-98-6

上下游产品

CAS号104-90-5 2-甲基-5-乙基吡啶 | CAS号50-00-0 甲醛 | CAS号85583-54-6 5-乙基-2-[2-(4-硝基... | CAS号5408-74-2 5-乙基-2-乙烯基吡啶 | CAS号105355-25-7 2-溴-3-[4-[2-(5-... | CAS号105355-26-8 2-氨基-5-[4-[2-(5... | CAS号144809-27-8 5-Ethyl-2-pyrid... | CAS号112529-15-4 盐酸吡格列酮 | CAS号136401-70-2 5-(4-(2-(5-乙基吡啶... | CAS号144809-28-9 5-[[4-[2-(5-乙基-... | CAS号114393-97-4 4-[2-(5-乙基-2-吡啶... | CAS号105355-27-9 匹格列酮

5-乙基-2-甲基-吡啶置于聚合甲醛体系中,化学反应生成 5-乙基-2-吡啶乙醇
参考文献:Processes For Preparing Pioglitazone And Its Pharmaceutically Acceptable Salts
标题:Processes For Preparing Pioglitazone And Its Pharmaceutically Acceptable Salts
摘要:通过在钴离子和二甲基苯并二酮的存在下,用氢硼酸钠还原5-[4-[2-(5-乙基-2-吡啶基)乙氧基]苯并基]-2,4-噻唑二酮,制备吡格列酮及其药用盐的改进工艺.更具体地说,使用的钴离子是六水合氯化钴或六水合硝酸钴(II),溶剂为dmf和水的混合物.

专利信息

专利号:WO-2009148195-A1
优先权日:2008-06-02
标题:5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same
发明人：PARK JIN OH; KIM YONG GIL; SON HAN IL; LEE YUN JEONG; KIM EUN MI
权利人:DAEBONG LS LTD; PARK JIN OH; KIM YONG GIL; SON HAN IL; LEE YUN JEONG; KIM EUN MI
摘要:The present invention relates to 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by the following Chemical Formula [1], which is useful as an intermediate for synthesis of thiazolidinedione based compounds, a method for preparing the compound, and a method for preparing pioglitazone or pioglitazone hydrochloride, which is a thiazolidinedione based drug and useful in treating and preventing diabetes, using the 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by Chemical Formula [1] as an intermediate:

专利号:EP-1694646-B1
优先权日:2003-12-19
标题 :Process for the synthesis of pioglitazone hydrogen chloride
发明人：FISCHER JANOS; FODOR TAMAS; LEVAI SANDOR; PETENYI ENDRENE; PERENYI EVA
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to a process for the synthesis of pioglitazone hydrogen chloride - which is an antidiabetic drug - via novel intermediates by reacting 4-[2-(5-ethyl-2-pyridinyl)-ethoxy]-benzaldehyde salt of formula (II), wherein HX is: HCI, CF3COOH, C4H4O4, (COOH)2 with a base and then thiazolidine-2,4-dione, and the obtained 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione base is treated with hydrochloric acid and the obtained 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl] methylene]-2,4-tiazolidinedione hydrogen chloride of formula(III) is hydrogenated in the presence of a catalyst. Further objects of the invention are the salts of general formula (II) and the benzylidene derivative of formula (III).

专利号:US-11767317-B1
优先权日:2020-06-30
标题:Methods of synthesizing enantiopure deuterium-enriched pioglitazone
发明人：NAVARRE LAURE FRANÇOISE VALÉRIE; JACQUES VINCENT; BOLZE SÉBASTIEN
权利人:POXEL SA
摘要:The invention provides methods of synthesis of enantiopure deuterium enriched R-pioglitazone with structure of compound (IV), or a pharmaceutically acceptable salt thereof: n nThe invention further provides chemical intermediates useful in the synthesis of compound (IV), and methods of synthesizing those intermediates.

专利号:WO-03029251-A1
优先权日:2001-09-28
标题 :Novel process for the synthesis of thiazolidinedione derivatives
发明人：UJIRE SANDHYA; SRIDHARAN MADHAVAN; GANESH SAMBASIVAM
权利人:BIOCON LTD; UJIRE SANDHYA; SRIDHARAN MADHAVAN; GANESH SAMBASIVAM
摘要:Compounds of formula (I), which are useful in the treatment of non-insulin dependent diabetes, and wherein Ar is optionally substituted heteroaryl, X is CH or N, R is H or alkyl, and n is 1 or 2, are prepared by reacting compounds of formula (II) with compounds of formula (VI) wherein G is OH or F.

专利号:EP-1694646-A1
优先权日:2003-12-19
标题 :Process for the synthesis of pioglitazone hydrogen chloride

专利号:ES-2286712-T3
优先权日:2003-12-19
标 题 :PROCESS FOR THE SYNTHESIS OF HYDRO-CHLORIDE OF PIOGLITAZONA.