Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于盐酸,乙醇,水体系中,化学反应生成 薯蓣皂素 参考文献:Tsukamoto; Kawasaki,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japanchem.Abstr.,1954,Vol. 74,P. 1127 标题:Tsukamoto; Kawasaki,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japanchem.Abstr.,1954,Vol. 74,P. 1127
专利号:US-2024287126-A1 优先权日:2021-05-14 标 题:Novel synthesis of cholesterol 发明人:SCHINZER DIETER; SPIESS OLIVER; MUNT MAXIM; INDOLESE ADRIANO; ROUX LIONEL 权利人:CORDENPHARMA INT GMBH; UNIV OTTO VON GUERICKE MAGDEBURG; CORDENPHARMA INT 摘要:The invention relates to a synthesis of cholesterol; a ring opening step of the compound of formula (I) and subsequent activation and reduction step yielding cholesterol. The inventions relates also to intermediates achieved during said synthesis.
专利号:US-10751419-B2 优先权日:2014-05-01 标题:Method for synthesis of reactive conjugate clusters 发明人:MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E 权利人:IONIS PHARMACEUTICALS INC 摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.
专利号:US-12146136-B2 优先权日:2020-03-26 标题:Synthesis of modified oligonucleotides with increased stability 发明人:KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN 权利人:UNIV MASSACHUSETTS 摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.
专利号:WO-2009033499-A1 优先权日:2007-09-13 标 题 :Total synthesis of enantiopure desogestrel 发明人:TIETZE LUTZ FRIEDJAHN; KRIMMELBEIN IIGA KRISTINE 权利人:UNIV GOETTINGEN GEORG AUGUST; TIETZE LUTZ FRIEDJAHN; KRIMMELBEIN IIGA KRISTINE 摘要:The present invention relates to a total synthesis of desogestrel and derivatives thereof, and to intermediate compounds of this synthesis.
专利号:US-9943544-B2 优先权日:2015-03-18 标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer 发明人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH 权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH 摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.
专利号:US-7662401-B2 优先权日:2002-04-08 标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase 发明人:MAHE YANN; MEYBECK ALAIN 权利人:OREAL 摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.
1: Tharaheswari M, Jayachandra Reddy N, Kumar R, Varshney KC, Kannan M, Sudha Rani S. Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats. Mol Cell Biochem. 2014 Jul 29. [Epub ahead of print]
合成参考文献
摘要:Huang BM, Yao CW, Bian QQ, Wang ZG, Mo JY. [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis]. Yao Xue Xue Bao. 2011 Apr;46(4):443–6. 参考文献:10.1016/j.ejmech.2011.06.015 摘要:Liu J, Ma Q, Huang Q, Yang W, Zhang J, Wang J, Zhu W, Yu X. Cationic lipids containing protonated cyclen and different hydrophobic groups linked by uracil-PNA monomer: Synthesis and application for gene delivery. European Journal of Medicinal Chemistry. 2011 Sep;46(9):4133–41. doi: 10.1016/j.ejmech.2011.06.015.