📜Rhusopolyphenol F置于三苯基膦,偶氮二甲酸二乙酯体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,以78%的收率获得产物漆黄素 (紫铆素)
参考文献:Polyphenols From The Bark Of Rhus Verniciflua And Their Biological Evaluation On Antitumor And Anti-Inflammatory Activities
标题:Polyphenols From The Bark Of Rhus Verniciflua And Their Biological Evaluation On Antitumor And Anti-Inflammatory Activities
摘要:Bioassay-Guided Fractionation And Chemical Investigation Of The Extract Of Rhus Verniciflua Bark Resulted In The Identification Of Six Polyphenols,Rhusopolyphenols A-F (1-6),Together With Four Known Compounds Including (2R,3S,10S)-7,8,9,13-Tetrahydroxy-2-(3,4-Dihydroxyphenyl)-2,3-Trans-3,4-Cis-2,3,10-Trihydrobenzopyrano[3,4-C]-2-Benzopyran-1-One (7),Peapolyphenol C (8),Cilicione-B (9) And (Alpha R)-Alpha,3,4,2',4'-Pentahydroxydihydrochalcone (10). The Structures Of These Polyphenols Were Elucidated By Spectroscopic Analysis,Including 1D And 2D NMR,And Hr-Esims,And Their Absolute Configurations Were Further Confirmed By A Combination Of Chemical Methods And Cd Data Analysis. All Isolates Were Evaluated For Their Antiproliferative Activities Against Four Human Tumor Cell Lines (A549,Sk-Ov-3,Sk-Mel-2,And Hct-15),And Compounds 4-6,9 And 10 Showed Antiproliferative Activity Against The Tested Cells,With Ic50 Values Of 3.31-18.51 Mu M. On The Basis Of The Expanded Understanding That Inflammation Is A Crucial Cause Of Tumor Progression,The Anti-Inflammatory Activities Of These Compounds Were Determined By Measuring Nitric Oxide (No) Levels In The Medium Of Murine Microglia Bv-2 Cells. Compounds 5 And 10 Significantly Inhibited No Production In Lipopolysaccharide (Lps)-Stimulated Murine Microglia Bv-2 Cells With Ic50 Values Of 28.90 And 12.70 Mu M,Respectively. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Phytochem.2013.05.005