CAS: 492-14-8; (-)-Butin

该化合物是一种有机化合物,其特征为碳基功能组和两个氢氧基组,是一种手性分子,其"(-)"名称表明其特定的光学活动,意即它可以逆时方向旋转飞机极光,该化合物一般是一种无色液体,由于存在可形成氢联结的氢氧氟化物,在水中可溶解.该化合物的结构包括一个四碳链,在第二和第三碳原子之间有三重联,有助于其再活动. (-)-丁(Butin)用于各种化学合成,并可作为生产药品和其他有机化合物的中间体.此外,其立体化学学可以影响衍生物的生物活动,使其对药用化学感兴趣.应当参考安全数据,因为许多有机化合物,如果处理不当,它可能会对健康造成危害.

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上下游产品

(+)-Fustin3',4',7-trihydroxyisoflavone

合成工艺路线路线简述

    📜Rhusopolyphenol F置于三苯基膦,偶氮二甲酸二乙酯体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,以78%的收率获得产物漆黄素 (紫铆素)
    参考文献:Polyphenols From The Bark Of Rhus Verniciflua And Their Biological Evaluation On Antitumor And Anti-Inflammatory Activities
    标题:Polyphenols From The Bark Of Rhus Verniciflua And Their Biological Evaluation On Antitumor And Anti-Inflammatory Activities
    摘要:Bioassay-Guided Fractionation And Chemical Investigation Of The Extract Of Rhus Verniciflua Bark Resulted In The Identification Of Six Polyphenols,Rhusopolyphenols A-F (1-6),Together With Four Known Compounds Including (2R,3S,10S)-7,8,9,13-Tetrahydroxy-2-(3,4-Dihydroxyphenyl)-2,3-Trans-3,4-Cis-2,3,10-Trihydrobenzopyrano[3,4-C]-2-Benzopyran-1-One (7),Peapolyphenol C (8),Cilicione-B (9) And (Alpha R)-Alpha,3,4,2',4'-Pentahydroxydihydrochalcone (10). The Structures Of These Polyphenols Were Elucidated By Spectroscopic Analysis,Including 1D And 2D NMR,And Hr-Esims,And Their Absolute Configurations Were Further Confirmed By A Combination Of Chemical Methods And Cd Data Analysis. All Isolates Were Evaluated For Their Antiproliferative Activities Against Four Human Tumor Cell Lines (A549,Sk-Ov-3,Sk-Mel-2,And Hct-15),And Compounds 4-6,9 And 10 Showed Antiproliferative Activity Against The Tested Cells,With Ic50 Values Of 3.31-18.51 Mu M. On The Basis Of The Expanded Understanding That Inflammation Is A Crucial Cause Of Tumor Progression,The Anti-Inflammatory Activities Of These Compounds Were Determined By Measuring Nitric Oxide (No) Levels In The Medium Of Murine Microglia Bv-2 Cells. Compounds 5 And 10 Significantly Inhibited No Production In Lipopolysaccharide (Lps)-Stimulated Murine Microglia Bv-2 Cells With Ic50 Values Of 28.90 And 12.70 Mu M,Respectively. (C) 2013 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Phytochem.2013.05.005

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    专利信息


    专利号:US-12036300-B2
    优先权日:2021-03-31
    标题:Methods and compositions for improving skin
    发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
    权利人:OREAL
    摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

    专利号:DE-4120446-A1
    优先权日:1991-06-20
    标 题:METHOD AND DEVICE FOR THE SYNTHESIS OF BUTINDIOL

    专利号:WO-2015140300-A1
    优先权日:2014-03-20
    标 题:Method and device for producing olefins
    发明人:HÖFEL TORBEN; SCHMADERER HARALD; PESCHEL ANDREAS
    权利人:LINDE AG
    摘要:The invention relates to a method (100) for producing olefins, wherein oxygenates are produced in one or more oxygenate synthesis steps (1, 2) by using hydrocarbons, hydrogen being obtained in the process, which oxygenates are then at least partially converted into hydrocarbons in one or more oxygenate conversion steps (3), and wherein in one or more steam cracking steps (4) hydrocarbons are produced, wherein some of the hydrocarbons from the one or more oxygenate conversion steps (3) and/or some of the hydrocarbons from the one or more steam cracking steps (4) are reacted with hydrogen in one or more hydrogenation steps (6). According to the invention the hydrogen obtained in the one or more oxygenate synthesis steps (1, 2) is at least partially used in the one or more hydrogenation steps (6). The invention further relates to a corresponding plant.

    专利号:US-2004203308-A1
    优先权日:2003-04-09
    标题:Process for making absorbent material
    发明人:KO YOUNG CHAN; KELLENBERGER STANLEY R; MAKOUI KAMBIZ BAYAT
    摘要:A process for making an absorbent material involves flash-drying a superabsorbent polymer precursor composition. The process may be used to make a superabsorbent-fiber material without the necessity of mixing conventional superabsorbent solid particles with pulp fluff is provided. The synthesis (i.e., polymerization) of the superabsorbent is completely integrated into the process for forming the absorbent material. One or more streams of superabsorbent polymer precursor composition are provided, to which a plurality of individual fibers may be added. The resulting in-situ polymerized superabsorbent-fiber material is then flash-dried and can subsequently be formed into a superabsorbent-fiber composite. The flash-drying is relatively inexpensive and requires little drying time compared to conventional drying methods.

    专利号:WO-2005059141-A1
    优先权日:2003-12-17
    标题 :Method of constructing yellow flower by regulating flavonoid synthesis system

    专利号:US-6645407-B2
    优先权日:2001-12-14
    标题:Process for making absorbent material with in-situ polymerized superabsorbent
    发明人:KELLENBERGER STANLEY R; JACKSON DAVID MARTIN; KO YOUNG C; SOERENS DAVE A; LAUMER JASON M; RANGANATHAN SRIDHAR
    权利人:KIMBERLY CLARK CO
    摘要:A process for making an absorbent composite including absorbent fibers, superabsorbent polymer and, optionally, thermoplastic fibers and other ingredients is provided. The synthesis (i.e., polymerization) of the superabsorbent is completely integrated into the process for forming the absorbent composite. Specifically, the polymerization of superabsorbent is initiated from within a plurality of absorbent and/or thermoplastic fibers, which are then formed into a web. The integrated process eliminates the need for separate manufacture of superabsorbent polymer prior to the fiber forming and web forming processes. Also, the superabsorbent polymer thus formed tends to disperse better and remain adhered to the absorbent and/or thermoplastic fibers, providing a stable and uniform absorbent composite for various end use applications.

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    合成参考文献


    参考文献:10.3390/ijms12063871
    摘要:Zhang R, Lee IK, Piao MJ, Kim KC, Kim AD, Kim HS, Chae S, Kim HS, Hyun JW. Butin (7,3',4'-trihydroxydihydroflavone) reduces oxidative stress-induced cell death via inhibition of the mitochondria-dependent apoptotic pathway. Int J Mol Sci. 2011;12(6):3871–87.
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