CAS: 4448-75-3; (Hydroxymethyl)Cycloheptane

相似化合物

1460-16-8 4277-29-6 32777-26-7

上下游产品

cycloheptanoic acid (4Z)-cyclohept-4-en-1-ylmethanol 1-hydroxymethyl-1-cycloheptene 1-Oxa-spiro[2.6]nonane 1-(bromomethyl)cycloheptane cis-Cyclo°Ctene -cycloheptan, Cycloheptanemethyl-brosylate4-Brom-benzolsulfonyl-oxymethyl-cycloheptan, Cycloheptanemethyl-brosylate 1-methylcycloheptene

📜乙酸环庚基甲基酯置于甲醇,Potassium Permanganate,三甲基碘化锍体系中,25.0 °C,101.33 Kpa 条件下,以99%的收率获得产物环庚烷甲醇
参考文献:Me3Si 促进的化学选择性脱乙酰化:一般和温和的方案.
标题:Me3Si 促进的化学选择性脱乙酰化:一般和温和的方案.
摘要:通过使用 Kmno4 作为添加剂,开发了一种 Me3Si 介导的简单而有效的乙酰基化学选择性脱保护方案.这种化学选择性脱乙酰化适用于多种底物,可耐受碳水化合物,氨基酸,天然产物,杂环化合物和一般支架中的多种敏感官能团.该协议很有吸引力,因为它使用环境友好的试剂系统在环境条件下进行定量和清洁转化.
DOI:10.1039/d1Ra03209G

专利信息

专利号:US-5637757-A
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds
发明人：HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
权利人:GREAT LAKES CHEMICAL CORP
摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:WO-2010115869-A1
优先权日:2009-04-03
标 题 :Propofol phosphonyl derivatives, synthesis, and use in long acting formulations
发明人：GONNISSEN YVES RENE JOHANNA PAUL
权利人:SEPS PHARMA N V; GONNISSEN YVES RENE JOHANNA PAUL
摘要:This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH 2 ) P -O-, a single bond, formula (IA), -(CH 2 ) 1-8 -O-X(O)-, and - p is an integer from 1 to 8, - each R 3 and each R 4 is independently selected from the group consisting of C 1-20 alkyl, C 3-12 alkyl, C 3-12 cycloalkyl-C 1-4 alkyl, saturated heterocyclyl and saturated heterocyclyl-C 1-4 alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR 5 , - W is selected from the group consisting of halogen, OH, S(O)H and O - M + wherein M + is a monovalent cation; and - R 5 is selected from the group consisting of hydrogen and C 1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.

专利号:WO-9632368-A1
优先权日:1995-04-11
标题:One-pot synthesis of ring-brominated benzoate compounds

专利号:EP-0825974-A1
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds