CAS: 321-60-8; 2-Fluoro-1,1'-Biphenyl

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CAS号17763-65-4 (2-phenylphenyl... | CAS号348-52-7 邻氟碘苯 | CAS号98-80-6 苯硼酸 | CAS号1072-85-1 1-溴-2-氟苯 | CAS号348-51-6 2-氯氟苯 | CAS号2633-57-0 三烯丙基(苯基)硅烷 | CAS号591-50-4 碘苯 | CAS号1993-03-9 2-氟苯硼酸 | CAS号143-66-8 四苯硼钠 | CAS号4688-76-0 2-联苯硼酸 | CAS号365-12-8 2'-氟-[1,1'-联苯]-4-羧酸 | CAS号169618-84-2 2,6-diphenylben... | CAS号215175-83-0 methyl 2-[4-(4-... | CAS号345-55-1 1-(2'-fluoro[1,... | CAS号4501-39-7 1-环己烷-4-乙基苯

2-联苯硼酸置于silver Trifluoromethanesulfonate,Sodium Hydroxide,Cf3O3S(1-)*c25H20Bfn9Pd(1+),4,7-二苯基-1,10-菲罗啉体系中,用 甲醇,乙腈 用作溶剂,以99%的收率获得2-氟联苯
参考文献:Pd(iv)的亲电氟化机理:氟化物捕获和随后的氧化性氟化物转移
标题:Pd(iv)的亲电氟化机理:氟化物捕获和随后的氧化性氟化物转移
摘要:衍生自氟化物的亲电氟化试剂对于合成18F标记的正电子发射断层扫描(pet)分子是理想的.在这里,我们研究了pd(iv)络合物捕获氟化物并随后将其转移至亲核试剂的机理.由于在氟化物和pd(iv)之间快速形成外层络合物,即使在18F放射性合成中通常使用的纳摩尔至微摩尔氟化物浓度下,中间体pd(iv)-F的形成速率也很高.提议从pd(iv)-F络合物中进行随后的氟转移,以通过不寻常的set /氟化物转移/ Set机理进行.本手稿中详细介绍的发现提供了理论基础,适用于解决具有高比活度18F Pet成像的亲电氟化的更通用方法.
Doi:10.1039/c3Sc52367E

专利信息

专利号:US-6683205-B2
优先权日:2001-02-15
标 题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs
发明人：HOSSAIN M MAHMUN
权利人:WISYS TECHNOLOGY FOUND INC
摘要:A method of producing a compound of the formula: n and its pharmaceutically acceptable salts, wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic group; comprising: n (1) reacting a compound of the formula: n wherein Ar is as described above, with N 2 CHCOOR, wherein R is alkyl, in the presence of a catalytic amount of a Bronsted acid or Lewis acid to form a compound of the formula: n wherein Ar and R are as described above; and n (2) reacting the compound of formula (II) with a reducing agent in the presence of an alkyl amine to form a compound of the formula: n wherein Ar and R are as described above.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:WO-9000611-A1
优先权日:1988-07-15
标题 :Synthesis of stereospecific enzyme by non-chromosomal transformation of a host

专利号:US-4824970-A
优先权日:1985-07-31
标题 :Intermediates for the synthesis of carboxylic acids

专利号:WO-9822475-A1
优先权日:1996-11-21
标题:Synthesis of fluorophenyl boranes

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.