CAS: 2516-34-9; Cyclobutanamine

该化合物是一种环环状矿,其特点是四人环环环,附着氨基(-NH2),在室温下无色状黄色液体,具有独特的颗粒味.环丁胺的分子配方为C4H9N,具有相对较低的分子重量.这种化合物以中度极度的极度而著称,它能够参与氢结合,影响其在水和有机溶剂中的溶解性.Cyclobutylam主要用于有机合成,并作为生产药品和农用化学品的中间体.它的再活性可归因于该矿组的存在,使其在各种化学反应中成为潜在的核素.此外,环丁胺的独特环状结构可产生特定的消毒性能和电子性能,从而有利于设计含有理想生物活动的化合物.在处理该物质时,应注意安全防范措施,因为如果吸入吸入或吸入,可能会对健康造成危害.

结构式图片

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6291-01-6 56700-66-4 32861-52-2

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上下游产品

CAS号3721-95-7 环丁基甲酸 | CAS号2625-41-4 硝基环丁烷 | CAS号2972-05-6 环丁烷酮肟 | CAS号56700-66-4 Tert-butyl cycl... | CAS号1503-98-6 环丁烷甲酰胺 | CAS号7726-95-6 溴素 | CAS号110192-07-9 N-chlor°Cyclobu... | CAS号359880-05-0 N-环丁基-4-哌啶酮 | CAS号151390-02-2 2-Pyrimidinamin... | CAS号201223-82-7 N-cyclobutyl-7-... | CAS号32861-52-2 N-Cyclobutylben... | CAS号325168-08-9 2-chloro-N-cycl... | CAS号1191-95-3 环丁酮 | CAS号110-15-6 琥珀酸; 丁二酸 | CAS号716316-26-6 N-cyclobutyl-2-... | CAS号75914-67-9 cyclobutylurea

合成工艺路线路线简述

  • 合成目标产物 Cyclobutylamine 主要起始原料 Cyclobutanone
  • (文献来源)合成步骤主要原料 Cyclobutanone
环丁酮置于palladium 10% On Activated Carbon,苄胺,氢气体系中,用 甲苯 用作溶剂,40.0~80.0 °C,3.04 Mpa 条件下,反应 34.0H,以72%的收率获得环丁基胺
参考文献:环丁胺的合成方法
标题:环丁胺的合成方法
摘要:本发明公开了一种环丁胺的合成方法,包括如下步骤:S1,高压釜内边搅拌边分别加入环丁酮,有机溶剂,催化剂和氨气;S2,向高压釜内通入氢气,保持通入的氢气压力为20‑30Atm,控制反应温度0‑100°C,反应12‑36H.本发明环丁胺的合成方法原料易得,合成条件温和,无需特别的安全措施,便于工业化生产.

专利信息


专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人:HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-2010191010-A1
优先权日:2007-07-02
标题 :Process for the synthesis of carbamates using co2
发明人:BOSMAN JORIS KAREL PETER; CARR ROBERT HENRY
权利人:HUNTSMAN INT LLC
摘要:Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO 2 in the presence of ionic liquids and optionally in the presence of a base.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-7157477-B2
优先权日:2000-10-25
标题 :Aliphatic amino-substituted demethoxylated hypocrellins and their synthesis
发明人:ZHANG MANHUA; XU SHANGJIE; WU TAO; CHEN SHEN; SHEN TAO
权利人:INST OF PHOTOGRAPHIC CHEMISTRY
摘要:The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed. The present invention relates to the field of photosensitizers possessing photodynamic activities. They possess high photodynamic activities and low dark toxicities, which makes them as more potent photodynamic agents than HPD against cancer and AIDS virus.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人:HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
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主要参考文献

[参考文献]: Hartmut Schirok, Et Al. Microwave-Assisted Flexible Synthesis Of 7-Azaindoles. J Org Chem. 2006 Jul 21;71(15):5538-45.

合成参考文献


摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 247.
摘要:Liang, Y.; Wen, Z.; Cabrera, M.; Howlader, A. H.; Wnuk, S. F., Science of Synthesis Knowledge Updates, (2020) 1, 302.
摘要:Aitken, R. A.; Meehan, A., Science of Synthesis Knowledge Updates, (2014) 3, 194.
摘要:Bartsch, S.; Vogel, A., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 298.
摘要:Folgueiras-Amador, A. A.; Wirth, T., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 173.
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