专利号:US-9475837-B2 优先权日:2011-12-23 标题 :Process for the synthesis of therapeutic peptides 发明人:HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK 权利人:IPSEN MFG IRELAND LTD 摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.
专利号:US-9388212-B2 优先权日:2013-02-21 标 题:Solid phase peptide synthesis via side chain attachment 发明人:BARLOS KLEOMENIS K 权利人:CHEMICAL & BIOPHARMACEUTICAL LAB OF PATRAS S A 摘要:The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
专利号:US-2016045626-A1 优先权日:2007-01-11 标题 :Methods and Compositions for Improved Labeling of Targeting Peptides 发明人:MCBRIDE WILLIAM J; GOLDENBERG DAVID M 权利人:IMMUNOMEDICS INC 摘要:The present application discloses compositions and methods of synthesis and use of labeled targeting peptides, such as octreotide, octreotate, or other somatostatin analogs or derivatives. The targeting peptide may be labeled with a therapeutic or diagnostic isotope, such as 61 Cu, 62 Cu, 64 Cu, 67 Cu, 18 F, 19 F, 66 Ga, 67 Ga, 68 Ga, 72 Ga, 111 In, 177 Lu, 44 Sc, 47 Sc, 86 Y, 88 Y, 90 Y, 45 Ti or 89 Zr, preferably 18 F or 19 F. More preferably, the targeting peptide is NOTA-octreotate, NOTA-MPAA-octreotate, pyridine-NOTA-octreotate or triazole-NOTA-octreotate. The labeled targeting peptides may be used for detection, diagnosis, imaging and/or treatment of sst 2 + tumors, such as neuroendocrine tumors.
专利号:JP-6192657-B2 优先权日:2011-12-23 标 题 :Method for the synthesis of therapeutic peptides
专利号:US-2015045534-A1 优先权日:2011-12-23 标题:Process for the Synthesis of Therapeutic Peptides
专利号:CN-1837232-A 优先权日:2005-03-21 标 题:Process for solid phase synthesis of octreotide
[参考文献]: Ngoc-Duc Doan, Et Al. Solid-Phase Synthesis Of C-Terminal Azapeptides. J Pept Sci. 2015 May;21(5):387-91.
合成参考文献
参考文献:10.1007/s10895-020-02653-5 摘要:Yu S, Wang Z, Gao L, Zhang B, Wang L, Kong J, Li L. A Highly Selective and Sensitive Peptide-Based Fluorescent Ratio Sensor for Ag+. Journal of Fluorescence. 2020 Nov 20;31(1):237–46. doi: 10.1007/s10895-020-02653-5. 参考文献:10.1038/s41596-020-00407-y 摘要:Lindner S, Wängler C, Bailey JJ, Jurkschat K, Bartenstein P, Wängler B, Schirrmacher R. Radiosynthesis of [18F]SiFAlin-TATE for clinical neuroendocrine tumor positron emission tomography. Nat Protoc. 2020 Dec;15(12):3827–43. doi: 10.1038/s41596-020-00407-y.