2-乙酰基蒽-9,10-二酮置于sodium Hydroxide,聚合甲醛体系中,用 异戊醇 用作溶剂,化学反应生成蒽醌-2-羧酸 参考文献:Etienne,A. Et Al.,Bulletin De La Societe Chimique De France,1968,P. 650-654 标题:Etienne,A. Et Al.,Bulletin De La Societe Chimique De France,1968,P. 650-654
专利号:US-6531591-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:EP-1202998-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:US-6509486-B2 优先权日:2000-11-13 标题:Process for the synthesis of 2-carboxyanthraquinone by oxidation of 2-ethylanthraquinone with nitric acid 发明人:DEVIC MICHEL 权利人:ATOFINA 摘要:The present invention relates to a process for the synthesis of 2-carboxyanthraquinone from 2-ethylanthraquinone by oxidation of the said ethyl group by means of a nitric acid solution. Anthra-quinones are used in the manufacture of oxygen-absorbing films which make possible the preparation of packagings suited to the preservation of oxygen-sensitive products, such as foodstuffs.
专利号:US-5132437-A 优先权日:1991-02-12 标题:Synthesis of 1-aminoanthraquinone 发明人:ASLAM MOHAMMAD; AGUILAR DANIEL A 权利人:HOECHST CELANESE CORP 摘要:1-Aminoanthraquinone (1-AAQ) is synthesized by the reaction of 2-chlorobenzyl chloride and xylene in the presence of a solid acid catalyst to yield 2-chloro dimethyldiphenylmethane, subsequent oxidation of the methyl groups, ring closure to form a 1-chloroanthraquinone carboxylic acid, replacement of the 1-chloro group with ammonia, and decarboxylation.
专利号:US-5130448-A 优先权日:1991-02-12 标 题:Synthesis of 1-aminoanthraquinone 发明人:ASLAM MOHAMMAD; AGUILAR DANIEL A 权利人:HOECHST CELANESE CORP 摘要:1-Aminoanthraquinone (1-AAQ) is synthesized by the condensation of 2-substituted benzoic acid and xylene to yield 2-substituted-dimethylbenzophenone, subsequent oxidation of the methyl groups, ring closure to form a 1-substituted anthraquinone carboxylic acid, replacement of the 1-substituent with ammonia, and decarboxylation.
专利号:US-2025320550-A1 优先权日:2024-04-12 标 题 :Sequencing by synthesis using electroactively labeled 3-oh-modified nucleotides 发明人:FOMINA NADEZDA; DARVISH ARMIN; JOHNSON CHRISTOPHER; SHIN YOUNG SHIK; VUKASIN GABRIELLE; YAMA GARY; LANG CHRISTOPH; GRUMAZ CHRISTIAN; PILSL SEBASTIAN 权利人:ROBERT BOSCH GMBH 摘要:Systems and methods for nucleic acid sequencing are provided. Polynucleotide strands to be sequenced are immobilized to a surface, clonally amplified and primed for polynucleotide synthesis. Nucleotides modified with cleavable electroactive labels at the 3′-OH of the sugar ring are provided and are incorporated into the growing strand during synthesis. The labels of nucleotides that are successfully incorporated into the growing polynucleotide strand are cleaved via application of a stimulus after incorporation and are detected by an electronic nanosensor. The systems and methods described herein combine the high accuracy of SbS methods combined with the scalability and speed of semiconductor-based electrical detection mechanisms.
[参考文献]: Park Jg, Et Al. Anti-Inflammatory And Antinociceptive Activities Of Anthraquinone-2-Carboxylic Acid. Mediators Inflamm. 2016;2016:1903849. [参考文献]: A Bielawska, Et Al. L-Proline Analogues Of Anthraquinone-2-Carboxylic Acid: Cytotoxic Activity In Breast Cancer Mcf-7 Cells And Inhibitory Activity Against Topoisomerase I And Ii. Pol J Pharmacol. 2001 May-Jun;53(3):283-7. [参考文献]: A Bielawska, Et Al. Prolidase As A Prodrug Converting Enzyme. Ii. Synthesis Of Proline Analogue Of Anthraquinone-2-Carboxylic Acid And Its Susceptibility To The Action Of Prolidase. Rocz Akad Med Bialymst. 1998:43:201-9. [参考文献]: H H Cheng, Et Al. Pharmacodynamic And Pharmacokinetic Studies Of Anthraquinone 2-Carboxylic Acid On Passive Cutaneous Anaphylaxis In Rats. Res Commun Mol Pathol Pharmacol. 1999;105(1-2):97-103. [参考文献]: K Kino, Et Al. Possible Cause Of G-C-->C-G Transversion Mutation By Guanine Oxidation Product, Imidazolone. Chem Biol. 2001 Apr;8(4):369-78.
合成参考文献
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. 参考文献:10.1016/j.chroma.2004.03.018 摘要:Bernabé-Zafón V, Torres-Lapasió JR, Ortega-Gadea S, Simó-Alfonso EF, Ramis-Ramos G. Resolution of overlapped non-absorbing and absorbing solutes using either an absorption null-balance detection window or multivariate deconvolution applied to capillary electrophoresis of anionic surfactants. J Chromatogr A. 2004 May 21;1036(2):205–16. doi: 10.1016/j.chroma.2004.03.018.