CAS: 1129-37-9; 4-Nitrobenzaldoxime

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555-16-8 1011-84-3 619-72-7

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📜对硝基苯甲醛置于盐酸羟胺,Sodium Carbonate体系中,用 甲醇,水 用作溶剂,化学反应 3.0H,反应生成4-硝基苯甲醛肟
参考文献:新型取代的5-异恶唑青霉素的简明合成和抗菌活性
标题:新型取代的5-异恶唑青霉素的简明合成和抗菌活性
摘要:描述了一系列新的 5-异恶唑青霉素的合成,它们是通过将取代的异恶唑与 6-Apa 偶联获得的.还研究了使用铜 (I) 作为催化剂通过 1,3-偶极环加成反应大规模合成 3,5-二取代异恶唑.对代表性化合物进行了抗微生物活性测定,显示出对革兰氏阴性菌令人满意的抗微生物活性.
Doi:10.1002/jccs.200700092

专利信息

专利号:US-4780504-A
优先权日:1985-06-20
标 题 :Supports useful in solid phase synthesis of oligonucleotides
发明人：BUENDIA JEAN; NIERAT JEANINE
权利人:ROUSSEL UCLAF
摘要:Novel supports useful in solid phase synthesis of oligonucleotides of the formula I +TR wherein &cir& is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

专利号:US-8710210-B2
优先权日:2010-06-30
标题:Method of using N-thio compounds for oligonucleotide synthesis
发明人：HE YIGANG; SOROKIN VICTOR; MAZUR WIESLAW ADAM
权利人:HE YIGANG; SOROKIN VICTOR; MAZUR WIESLAW ADAM; GIRINDUS AMERICA INC
摘要:A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R 1 and R 2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.

专利号:US-6790946-B2
优先权日:1997-05-14
标题 :Synthesis of oligonucleotides
发明人：KWIATKOWSKI MAREK; LANDEGREN ULF; NILSSON MATS
权利人:QUIATECH AB
摘要:A method of preparing an immobilized oligonucleotide having a free 3′-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3′-end and having a free 5′-end; ii) binding said oligonucleotide in a second position remote from the 3′-end to the solid support; and iii) selectively releasing the 3′-end of the oligonucleotide from the solid support to obta the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3′-end.

专利号:US-5908926-A
优先权日:1995-03-16
标题:5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
发明人：PIRRUNG MICHAEL C; SHUEY STEVEN W; BRADLEY JEAN-CLAUDE
权利人:UNIV DUKE
摘要:The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5' to 3' nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5' end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.

专利号:US-2002051994-A1
优先权日:1997-05-14
标题 :Synthesis of oligonucleotides

专利号:US-2012071640-A1
优先权日:2008-12-23
标题 :Sulfurizing reagents and their use for oligonucleotides synthesis
发明人：MAZUR WIESLAW ADAM; HE YIGANG; SOROKIN VICTOR D
权利人:MAZUR WIESLAW ADAM; HE YIGANG; SOROKIN VICTOR D; GIRINDUS AMERICA INC
摘要:An oligonucleotide which comprises at least one internucleotide linkage comprising a P—S—R bond and at least two nucleosides, wherein R corresponds to the formula (I) n n n n n n n n n n wherein A is a geminally substituted alkylene group, preferably CH 2 , X and Y are independently selected from S and O, and R 0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof. Other nucleotides described comprise at least one internucleotide linkage comprising a P—S—R bond, at least one internucleotide linkage comprising a P—S—R′ bond and at least three nucleosides wherein R′ is an organic residue other than the group R, preferably selected from a group consisting of an aryl group and a heteroaryl group which is bonded to the S-atom through an annular carbon atom.