CAS: 104012-37-5; (1S,3Ar,5R,7S,7As)-1-((R)-1-Acetoxyethyl)-7-Isopropyl-4-Methylene-2-Oxooctahydro-1H-Inden-5-Yl (E)-3-Methylpent-2-Enoate
该化合物其结构特征为独特的松动环和异卵激素细胞,它具有调节炎症途径的潜力,如NF-B抑制剂.它的低毒性特征和自然来源进一步支持其在治疗发展中的应用性.研究表明,在减轻空气道高反应和氧化压力方面的效力,突出其与肺部和心血管研究的相关性.HPLC和LC-MS等分析方法确保标准化应用的精确量化.
- 英文名称(1S,3Ar,5R,7S,7As)-1-((R)-1-Acetoxyethyl)-7-Isopropyl-4-Methylene-2-Oxooctahydro-1H-Inden-5-Yl (E)-3-Methylpent-2-Enoate
- 中文名称款冬酮
- IUPAC名称(1S,3aR,5R,7S,7aS)-1-((R)-1-acetoxyethyl)-7-isopropyl-4-methylene-2-oxooctahydro-1H-inden-5-yl (E)-3-methylpent-2-enoate
- CAS编号104012-37-5
- MFCD编号:MFCD32004666
- FDA UNII编号:95N0GBB2SX
- 分子式:C23H34O5分子量:390.52
- 产品CID: 77440
- 产品分类天然产物 → 倍半萜
物理性质
合成工艺路线路线简述
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Kim YK, Yeo MG, Oh BK, Kim HY, Yang HJ, Cho SS, Gil M, Lee KJ. Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced Septic Mice. Int J Mol Sci. 2017 Dec 18;18(12). pii: E2744. doi: 10.3390/ijms18122744.
2: Cheng X, Liao M, Diao X, Sun Y, Zhang L. Screening and identification of metabolites of two kinds of main active ingredients and hepatotoxic pyrrolizidine alkaloids in rat after lavage Farfarae Flos extract by UHPLC-Q-TOF-MS mass spectrometry. Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4047. Epub 2017 Aug 18. doi: 10.1016/j.chroma.2017.02.005. Epub 2017 Feb 3.
5: Lee J, Kang U, Seo EK, Kim YS. Heme oxygenase-1-mediated anti-inflammatory effects of tussilagonone on macrophages and 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice. Int Immunopharmacol. 2016 May;34:155-164. doi: 10.1016/j.intimp.2016.02.026. Epub 2016 Mar 5. doi: 10.1002/rcm.7262. doi: 10.4103/0973-1296.160473.
合成参考文献
参考文献:10.1126/science.1174621
摘要:Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 01;327(5961):46–50. doi: 10.1126/science.1174621.
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