CAS: 10338-69-9; 4-Phenyl-1,2,3,6-Tetrahydropyridine

相似化合物

43064-12-6 186347-72-8 38025-45-5

上下游产品

CAS号186347-72-8 4-苯基-3,6-二氢-2H-... | CAS号40807-61-2 4-羟基-4-苯基哌啶 | CAS号43064-12-6 4-苯基-1,2,3,6-四氢吡啶盐酸盐 | CAS号98-83-9 α-甲基苯乙烯 | CAS号19798-94-8 tetrahydro-6-me... | CAS号79099-07-3 1-B°C-4-哌啶酮 | CAS号108-86-1 溴苯 | CAS号28289-54-5 1-甲基-4-苯基-1,2,3... | CAS号138647-49-1 3,6-二氢-4-[[(三氟甲... | CAS号172734-33-7 4-羟基-4-苯基哌啶-1-羧酸叔丁酯 | CAS号109241-03-4 (2-iodophenyl)-... | CAS号939-23-1 4-苯基吡啶 | CAS号771-99-3 4-苯基哌啶 | CAS号34273-01-3 4-N-甲基苄基-n-乙氧甲酰... | CAS号80866-85-9 4-BROMO-4-PHENY... | CAS号819862-71-0 ethyl 4-(4-phen... | CAS号98323-83-2 3-[4-(3,6-二氢-4-... | CAS号38025-45-5 1-苄基-1,2,3,6-四氢...

4-苯基-4-羟基哌啶置于盐酸体系中,化学反应 24.0H,以68%的收率获得4-苯基-1,2,3,6-四氢吡啶
参考文献:Structure-activity Relationship Exploration Of Kv1.3 Blockers Based On Diphenoxylate
标题:Structure-activity Relationship Exploration Of Kv1.3 Blockers Based On Diphenoxylate
摘要:Diphenoxylate,A Well-Known Opioid Agonist And Anti-Diarrhoeal Agent,Was Recently Found To Block Kv1.3 Potassium Channels,Which Have Been Proposed As Potential Therapeutic Targets For A Range Of Autoimmune Diseases. The Molecular Basis For This Kv1.3 Blockade Was Assessed By The Selective Removal Of Functional Groups From The Structure Of Diphenoxylate As Well As A Number Of Other Structural Variations. Removal Of The Nitrile Functional Group And Replacement Of The C-4 Piperidinyl Substituents Resulted In Several Compounds With Submicromolar Ic50 Values. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2012.09.080

专利信息

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:WO-0010565-A1
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI; DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:WO-2010007202-A1
优先权日:2008-07-17
标 题:Enzymatic synthesis of enantiomerically enriched derivatives of cis- and trans-cyclopentane-1,2-diamines

专利号:EP-2319825-A1
优先权日:2008-07-17
标 题 :Enzymatic synthesis of enantiomerically enriched derivatives of cis- and trans-cyclopentane-1,2-diamines

专利号:US-4546177-A
优先权日:1979-02-13
标题:1-(6-Hydroxy-4- or -7-methoxy-5-Benzofuranyl)-4-substituted-1,3-butanediones
发明人：GAMMILL RONALD B
权利人:UPJOHN CO
摘要:The present invention provides novel 1-(6-hydroxy-4- or 7-methoxy or 4,7-dimethoxy-5-benzofuranyl)-4-substituted-1,3-butanediones which are useful as intermediates in the synthesis of khellin and related anti-atherosclerotic furochromones.