CAS: 97745-69-2; N2,Nd,Nw-Tris(Tert-Butoxycarbonyl)-L-Arginine

该化合物是一种受保护的氨酸衍生物,含有多种三丁基碳基(Boc)组,加强了稳定性,便于有选择地在peptide合成中取消保护.化合物的guadino和氨基功能是引入正弦类结构模型,同时最大限度地减少侧反应的关键.高纯度和定义明确的立体化学确保固相和溶解相聚的固相和聚的可靠性能.博克组提供正向保护,使对复杂的peptide组装有控制的连续保护.这种试剂在药用化学和生物聚合中特别有用,因为精确的功能组装在其中非常关键.它具有很强的特性,而且与标准的混合试剂相兼容性在合成中进一步强调了其效用.

结构式图片

相似化合物

1119-34-2 114622-81-0 1159-15-5

物理性质

MSDS等安全信息

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate t-butyloxycarbonyl-L-arginine5,N10-di-tert-butoxycarbonyl-spermine-Nα,Nδ,Nω-tri-tert-butoxycarbonyl-L-arginine amide6-carbobenzoxyamin°Caproic-N5,N10-di-tert-butoxycarbonyl-spermine-Nα,Nδ,Nω-tri-tert-butoxycarbonyl-L-arginine amide -tyrosyl-N,N'-di-B°C-spermine-N-α-NG,NG'-tri-B°C-L-arginine-di-amideN-6-(p-azidobenzamide)-caproyl-tyrosyl-N,N'-di-B°C-spermine-N-α-NG,NG'-tri-B°C-L-arginine-di-amide G,G'-tri-B°C-L-arginine di-amideN-Cbz-tyrosyl-spermine-N-α-NG,G'-tri-B°C-L-arginine di-amide G,G'-tri-B°C-L-arginine di-amideH2N-tyrosyl-N,N'-di-B°C-spermine-α-NG,G'-tri-B°C-L-arginine di-amide

合成工艺路线路线简述

  • 24424-99-5 + 74-79-3 = 97745-69-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tert-Butanol,Water; 5 Min,0 °C1.2 0 °C; 48 H,Rt
    标题:Synthesis And Bioactivities Study Of New Antibacterial Peptide Mimics: The Dialkyl Cationic Amphiphilesdi-Tert-Butyl Dicarbonate
    作者:Zhang,En; Et Al Wakselman,Michel
    参考文献:European Journal Of Medicinal Chemistry 日期:2018 卷标:(2001) 页码:1489-1509]

    = 97745-69-2 [标题:Reaction Conditions
    标题:Activation Of Carboxylic Acids By Pyrocarbonates. Synthesis Of Arylamides Of N-Protected Amino Acids And Small Peptides Using Dialkyl Pyrocarbonates As Condensing Reagentsnα,Ng,Ng-Tri-Tert-Butyloxycarbonylarginine. A New Arginine Derivative For Peptide Synthesis
    作者:Pozdnev,V. F. Pozdnev,V. F.
    参考文献:International Journal Of Peptide & Protein Research 日期:1994 卷标:44(1) 页码:36-48]

    24424-95-1 = 97745-69-2
    反应条件:1.1 Catalysts: Dabco2.1 -
    标题:Di-Tert-Butyl Dicarbonate
    作者:Wakselman,Michel
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 页码:1-7]

    39982-09-7 = 97745-69-2
    反应条件:1.1 -2.1 Catalysts: Dabco3.1 -
    标题:Di-Tert-Butyl Dicarbonate
    作者:Wakselman,Michel
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 页码:1-7]

    24424-99-5 + 13726-76-6 = 97745-69-2 + 17907-22-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 3 H,Rt; 39 H,Rt; Rt -> 0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,Rt
    标题:N,N,N-Tris(Tert-Butoxycarbonyl)-L-Arginine: Five Isoforms Whose Obtainment Depends On Procedure And Scrupulous Nmr Confirmation Of Their Structures
    作者:Alfei,Silvana; Et Al
    参考文献:Research On Chemical Intermediates 日期:2018 卷标:44(3) 页码:1811-1832]

    24424-99-5 + 1119-34-2 = 97745-69-2 + 17907-22-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 12 H,Rt2.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 3 H,Rt; 39 H,Rt; Rt -> 0 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 7,Rt
    标题:N,N,N-Tris(Tert-Butoxycarbonyl)-L-Arginine: Five Isoforms Whose Obtainment Depends On Procedure And Scrupulous Nmr Confirmation Of Their Structures
    作者:Alfei,Silvana; Et Al
    参考文献:Research On Chemical Intermediates 日期:2018 卷标:44(3) 页码:1811-1832

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合成参考文献


参考文献:10.1055/s-0037-1611773
摘要:Hollanders K, Maes B, Ballet S. A New Wave of Amide Bond Formations for Peptide Synthesis. Synthesis. 2019 Apr 24;51(11):2261–77. doi: 10.1055/s-0037-1611773.
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