CAS: 93-61-8; N-Methylformanilide

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CAS号64-18-6 甲酸 | CAS号100-61-8 N-甲基苯胺 | CAS号77287-34-4 甲亚胺酸 | CAS号149-73-5 原甲酸三甲酯 | CAS号103-70-8 甲酰苯胺 | CAS号74-88-4 碘甲烷 | CAS号66-25-1 正己醛 | CAS号121-69-7 N,N-二甲基苯胺 | CAS号67-66-3 氯仿 | CAS号104804-16-2 5-异丁基噻吩-2-甲醛 | CAS号2538-98-9 4-异丙氧基-3-甲氧基苯甲醛 | CAS号34123-66-5 3-异丙基-4-甲氧基苯甲醛 | CAS号127595-56-6 2,2',6,6'-tetra... | CAS号3392-97-0 2,6-二甲氧基苯甲醛 | CAS号35250-76-1 5-丙基-噻吩-2-甲醛 | CAS号57695-98-4 3-甲氧基-4-丙氧基苯甲醛 | CAS号5922-56-5 4-甲氧基-3-丙氧基苯甲醛 | CAS号34900-01-1 反式3-(N-甲基苯胺基)丙烯醛 | CAS号493-50-5 1-甲基-1,2,3,4-四氢...

N-苯基甲酰胺置于[rhcl{K3-P,C,P'=c(Nch2Pcy2)2C10H6}],苯硅烷体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 112.0H,反应生成 N-甲基甲酰苯胺
参考文献:基于铑过亚im基的nhc络合物催化的二氧化碳对胺的选择性甲酰化或甲基化反应
标题:基于铑过亚im基的nhc络合物催化的二氧化碳对胺的选择性甲酰化或甲基化反应
摘要:二氧化碳可以作为化学合成的可持续原料发挥至关重要的作用.为了可行,所采用的方案应尽可能温和.在本文中,我们报告了一种方法,该方法将co 2掺入由带有基于亚吡啶的nhc /膦钳型配体的rh(i)配合物催化的伯,仲,芳族或烷基胺中.基于perminide的配体属于通过螯合物辅助的双重ch活化获得的一类6元nhc配体.使用co 2气球进行胺的n-甲酰化和-甲基化和苯基硅烷作为还原剂.通过改变溶剂,化学反应温度和所用苯基硅烷的量来调节甲酰化和甲基化产物之间的产物选择性.获得了中等到出色的转化率,以及对一系列官能团的耐受性.在催化和时程研究中与反应物的化学计量反应表明,感兴趣的甲酰化和甲基化反应始于co 2的氢化硅烷化,然后与胺底物反应.
DOI:10.1039/c8Gc03094D

专利信息

专利号:US-11661406-B2
优先权日:2018-08-13
标 题 :Method for producing intermediate useful for synthesis of SGLT inhibitor
发明人：LI QING RI; YOON HEE KYOON
权利人:DAEWOONG PHARMACEUTICAL CO LTD
摘要:A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

专利号:US-5118853-A
优先权日:1988-10-13
标题:Processes for the synthesis of 3-disubstituted aminoacroleins
发明人：LEE GEORGE T; REPIC OLJAN
权利人:SANDOZ LTD
摘要:Process for the synthesis of compounds of the formula ##STR1## comprising the steps of (i) reacting a compound of the formula ##STR2## with oxalyl chloride or oxalyl bromide to form the corresponding compound of the formula ##STR3## (ii) reacting said compound of the formula ##STR4## with a compound of the formula ##STR5## to form the corresponding compound of the formula ##STR6## (iii) hydrolyzing said compound of the formula ##STR7## to obtain the corresponding compound of the formula ##STR8## the use of the compounds of the formula ##STR9## for the synthesis of the compounds of the formula ##STR10## and the use of the intermediates of Formula VII for the direct synthesis of the compounds of Formula II, n wherein n R 1 is C 1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 1b is phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 2 is C 1-3 alkyl, n one of R 3 and R 4 is ##STR11## and the other is primary or secondary C 1-6 alkyl not containing an asymmetric carbon atom, C 3-6 cycloalkyl or phenyl-(CH 2 ) m -, n wherein n R 7 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 9 is hydrogen, C 1-2 alkyl, C 1-2 alkoxy, fluoro or chloro, and n m is 1, 2 or 3, with the provisos that not more than one of R 7 and R 8 is trifluoromethyl, not more than one of R 7 and R 8 is phenoxy, and not more than one of R 7 and R 8 is benzyloxy, n R 5 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 3-6 cycloalkyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, and n R 6 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy, or benzyloxy, with the provisos that not more than one of R 5 and R 6 is trifluoromethyl, not more than one of R 5 and R 6 is phenoxy, and not more than one of R 5 and R 6 is benzyloxy, n R 10 is C 1-6 alkyl, each X is chloro or bromo, and each X.sup.⊖ is chloride or bromide.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-5191087-A
优先权日:1991-07-24
标 题 :Process for the synthesis of 1,4-disubstituted pyrazoles
发明人：ALCARAZ JEAN-MARIE; LECACHEUR MARYSE; ROBIN YVES
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of 1,4-disubstituted pyrazoles. A monosubstituted hydrazine is reacted with the product of reaction of an acetal with an N-substituted halomethyliminium salt, preferably N,N-dimethylchloromethyliminium chloride. n The 1,4-disubstituted pyrazoles are, in particular, important intermediates in the synthesis of herbicides or drugs.

专利号:US-5290946-A
优先权日:1988-10-13
标 题 :Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
发明人：LEE GEORGE T; KAPA PRASAD K; REPIC OLJAN
权利人:SANDOZ LTD
摘要:A process for synthesizing compounds of the formula ##STR1## utilizing, as intermediates, oxalyl chloride or bromide and compounds of the formulae R 1 R 2 N--CHO and CH 2 â• CH--O--R 10 are processes for synthesizing compounds of the formula ##STR2## utilizing, as intermediates, compounds of Formula I wherein R 1 is phenyl or substituted phenyl or intermediates in the synthesis of the compounds of formula I which intermediates have the formula ##STR3## wherein R 1 is C 1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 2 is C 1-3 alkyl, n R 10 is C 1-6 alkyl, n X.sup.⊖ is chloride or bromide, and n R 3 -R 6 are as defined in the specification. n The compounds of Formula II are intermediates in the synthesis of known HMB-CoA reductase inhibitors which inhibit the biosynthesis of cholesterol and are useful as antihyperchloesterolemic gents.

专利号:US-10633360-B2
优先权日:2014-12-23
标题 :Efficient process for the synthesis of alkoxy substituted benzaldehydes
发明人：MOHAPATRA Manoj Kumar; BENDAPUDI Ramamohanrao; MENACHERRY Paul Vincent; PAUL VINCENT
权利人:ANTHEA AROMATICS PRIVATE LTD
摘要:The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.