CAS: 822-87-7; 2-Chlorocyclohexanone

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1561-86-0 7298-89-7 75091-99-5

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Cyclohexen-1-Ol置于n-氯代丁二酰亚胺,[{cp*ircl2}]2体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 24.0H,以92%的收率获得产物2-氯环己酮
参考文献:铱催化烯丙醇的 1,3-氢转移/氯化
标题:铱催化烯丙醇的 1,3-氢转移/氯化
摘要:串联:烯丙醇与n-氯代琥珀酰亚胺 (Ncs) 串联 1,3-H 位移/c-Cl 键形成反应,反应生成 α-氯酮和 α-氯醛.反应完全选择性地进行,得到单氯化羰基化合物的单一结构异构体.从烯丙醇直接合成 4,5-二取代 2-氨基噻唑说明了该转化的实用性.
DOI:10.1002/anie.201301013

专利信息

专利号:US-2007129554-A1
优先权日:2005-10-24
标题 :Alpha functionalization of cyclic, ketalized ketones and products therefrom
发明人：HARRINGTON PETER J; KHATRI HIRALAL N; KHATRI SUDHA
权利人:HARRINGTON PETER J; KHATRI HIRALAL N; KHATRI SUDHA
摘要:Methodologies for the alpha-monohalogenation of acid sensitive ketones, especially cyclic, acid-sensitive, ketalized ketones. As one approach, the ketone is reacted with a halogen donor compound, e.g., N-chlorosuccinimide, in anhydrous, highly polar organic reagents such as dimethylformamide (DMF). As another monohalogenation approach, it has been observed that organic salts generated from amines and carboxylic acids catalyze the monohalogenation of ketalized ketone in reagents comprising alcohol solvent (methanol, ethanol, isopropanol, etc.). The monohalogenation is fast even at −5° C. The salt can be rapidly formed in situ from ingredients including amines and/or carboxylic acids without undue degradation of the acid sensitive ketal. Aryl ketones are monooxygenated using iodosylbenzene. This methodology is applied to monohalogenation of an acid sensitive monoketal ketone. The ability to prepare monohalogenated, acid sensitive ketones facilitates syntheses using halogenated, acid sensitive ketones. As just one example, facile synthesis of halogenated, acid sensitive ketones provides a new approach to synthesize the S-ketal-acid S-MBA (S-methylbenzylamine) salt useful as an intermediate in the manufacture of a glucokinase activator. As an overview of this scheme, a monohalogenated, cyclic, ketalized ketone is prepared using monohalogenation methodologies of the present invention. The halogenated compound is then subjected to a Favorskii rearrangement under conditions to provide the racemic acid counterpart of the desired chiral salt. The desired chiral salt is readily recovered in enantiomerically pure form from the racemic mixture.

专利号:US-8604219-B2
优先权日:2009-08-24
标题 :Method for synthesis of N-alkyl carbazole and derivatives thereof
发明人：GHARDA KEKI HORMUSJI
权利人:GHARDA KEKI HORMUSJI
摘要:Disclosed is a process for the preparation of N-alkyl carbazole. Said process comprises: a) chlorinating cyclohexanone to form 2-chlorocyclohexanone; b) reacting 2-chlorocyclohexanone with N-ethyl aniline to form 2-(N-ethyl anilino)cyclohexanone; c) cyclizing 2-(N-ethyl anilino) cyclohexanone by refluxing with simultaneous water removal to obtain 9-ethyltetrahydrocarbazole; d) treating 9-ethyl-tetrahydrocarbazole with concentrated hydrochloric acid followed by water wash for removing N-ethyl aniline; e) dehydrogenating 9-ethyltetrahydrocarbazole by heating 9-ethyltetrahydrocarbazole in a solvent, in presence of a catalyst to obtain N-alkyl carbazole.

专利号:US-8618311-B2
优先权日:2005-06-15
标题:Synthetic processes for the preparation of aminocyclohexyl ether compounds
发明人：JUNG GRACE; YEE JAMES GEE KEN; CHOU DOUG TA HUNG; PLOUVIER BERTRAND M C
权利人:JUNG GRACE; YEE JAMES GEE KEN; CHOU DOUG TA HUNG; PLOUVIER BERTRAND M C; CARDIOME PHARMA CORP
摘要:This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): n nor a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R 3 , R 4 and R 5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.

专利号:US-5780603-A
优先权日:1996-11-15
标题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SYNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccaride derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccaride derviatives.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.

专利号:US-2003181466-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones