CAS: 77-38-3; 2-(1-(4-Chlorophenyl)-1-Phenylethoxy)-N,N-Dimethylethan-1-Amine
该化合物是一种主要用于镇静剂和抗乳性特性的抗口服和抗胆碱酯酶剂,属于被称为苯并呋喃的化合物类别,其特点是能够阻塞三聚胺H1受体,这有助于减轻过敏反应和症状,如痒痒和喷嚏等;氯苯氧胺的化学结构包括一个有助于其药理活动的苯氧类;它通常以口服形式进行,并有一定的行动开端;氯苯氧胺还可能出现某些中央...
- ⚠️《化妆品禁用原料目录》
- 英文名称2-(1-(4-Chlorophenyl)-1-Phenylethoxy)-N,N-Dimethylethan-1-Amine
- 中文名称氯苯沙明
- IUPAC名称2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethylethan-1-amine
- 其它别名Ethylamine,2-[(p-chloro-a-methyl-a-phenylbenzyl)oxy]-N,N-dimethyl-(6CI,7CI,8CI); 2-(p-Chloro-a-methyl-a-phenylbenzyloxy)-N,N-dimethylethylamine; Chlorphenoxamine; [1-(p-Chlorophenyl)-1-phenylethyl] (b-dimethylaminoethyl) ether; p-Chloro-a-methyldiphenhydramine; b-Dimethylaminoethyl (p-chloro-a-methylbenzhydryl) ether
- CAS编号77-38-3
- MFCD编号:MFCD00866588
- EINECS号:616-456-4
- FDA UNII编号:3UVD77BP8R
- 分子式:C18H22ClNO分子量:303.83
- 产品CID: 1767262
- 同类组份化合物CAS77-38-3 (free base)562-09-4 (HCl)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
MSDS等安全信息
欧盟法规
REACH注册ECHA物质ECHA物质C&L通报REACH预注册上下游产品
CAS号122-01-0 4-氯苯甲酰氯 | CAS号591-51-5 苯基锂 | CAS号134-85-0 4-氯二苯甲酮 | CAS号59767-24-7 1-(4-氯苯基)-1-苯基乙醇 | CAS号107-99-3 2-氯-N,N-二甲基乙胺合成工艺路线路线简述
📜4-氯二苯甲酮置于sodium Amide体系中,用 甲苯 作为反应溶剂,化学反应 8.0H,反应生成 氯苯沙明
参考文献:Organomanga+nese (II) Reagents Xiv1: A Short And Efficient Synthesis Of Diastereoisomeric (+/-)-α-Bisabolols And (+/-)-Chlorphenoxamine
标题:Organomanga+nese (II) Reagents Xiv1: A Short And Efficient Synthesis Of Diastereoisomeric (+/-)-α-Bisabolols And (+/-)-Chlorphenoxamine
摘要:
DOI:10.1016/s0040-4039(00)82147-4
海关参考信息
- 2902600000-乙苯
2903919090-氯苯
2906210000-苄醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: ULDALL PR, WALTON JN, NEWELL DJ. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1(5240):1649-52. doi: 10.1136/bmj.1.5240.1649.
2: KERLEY TL, RICHARDS AB, BEGLEY RW, ABREU BE, WEAVER LC. Anticonvulsant and antitremor effects of chlorphenoxamine. J Pharmacol Exp Ther. 1961 Jun;132:360-5. 28(3-4):591-600. doi: 10.1016/s0731-7085(01)00694-x.
4:638-49. doi: 10.1016/0041-008x(62)90091-1. 170(1):37-41. doi: 10.1001/jama.1959.03010010039008. 37(9):1062-4. 7(4):214-20. doi: 10.1002/j.1552-4604.1967.tb00050.x. 88(4):1126-34.
合成参考文献
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from
参考文献:10.1016/s0022-3565(25)26056-6
摘要:Kerley TL, Richards AB, Begley RW, Abreu BE, Weaver LC. ANTICONVULSANT AND ANTITREMOR EFFECTS OF CHLORPHENOXAMINE. The Journal of Pharmacology and Experimental Therapeutics. 1961 Jun;132(3):360–5. doi: 10.1016/s0022-3565(25)26056-6.
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