CAS: 7568-93-6; Phenylethanolamine

上下游产品

CAS号96-09-3 氧化苯乙烯 | CAS号1674-30-2 2-氯-1-苯乙醇 | CAS号35645-98-8 2-(2-hydroxy-2-... | CAS号7693-77-8 5-苯基-2-恶唑烷酮 | CAS号532-28-5 扁桃腈 | CAS号5468-37-1 2-氨基苯乙酮盐酸盐 | CAS号37733-99-6 (+/-)-1-[1-(ter... | CAS号613-89-8 2-氨基苯乙酮 | CAS号110339-51-0 N-3,4-DIMETHOXY... | CAS号109355-73-9 ethyl N-(2-hydr... | CAS号51096-49-2 S-(-)-2-苄基氨基-1-苯基乙醇 | CAS号1437-98-5 2-Thiazolidinet... | CAS号14746-52-2 Benzeneethanami... | CAS号4190-14-1 N-苯乙酮苯甲酰胺 | CAS号3963-62-0 2,2-二苯基乙胺 | CAS号92-71-7 2,5-二苯基噁唑 | CAS号2207-50-3 氨苯恶唑啉 | CAS号64-04-0 β-苯乙胺

2-异亚硝基苯乙酮置于lithium Aluminium Tetrahydride体系中,用 乙醚 作为反应溶剂,化学反应生成 2-氨基-1-苯乙醇
参考文献:α-羰基肟与酰胺醇的新型反应:酰胺醇,新型氧代氨基醇配体及其金属配合物的合成,表征,晶体结构和热学研究
标题:α-羰基肟与酰胺醇的新型反应:酰胺醇,新型氧代氨基醇配体及其金属配合物的合成,表征,晶体结构和热学研究
摘要:在这项研究中,观测到异亚硝基苯乙酮和1-苯基乙醇胺之间的新型反应.苯乙酮用作起始原料,在乙醇钠存在下,通过苯乙酮与亚硝酸正丁酯反应,合成异亚硝基苯乙酮,并通过在乙醚中用lialh 4还原异亚硝基苯乙酮,来合成1-苯基乙醇胺.当异亚硝基苯乙酮与1-苯基乙醇胺,(3 E)-3-氮杂-5-(羟基亚氨基)-1,4-二苯基戊-3-烯-1-醇一水合物反应时,获得了新的肟基醇配体和酰胺醇作为关联产品有趣.通过用金属盐如cu Ii,Ni Ii,Zn处理肟基醇制备了四种配合物ii和co Ii.通过单晶x射线衍射表征酰胺醇,并使用光谱技术和热重分析(tga)表征所有配合物.
DOI:10.1080/15533174.2011.591300

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-8853132-B2
优先权日:2008-11-27
标题 :Directed synthesis of oligophosphoramidate stereoisomers
发明人：HEINDL DIETER; KESSLER DIRK; ROESLER ANGELIKA; SEIDEL CHRISTOPH; THUER WILMA
权利人:ROCHE DIAGNOSTICS OPERATIONS
摘要:The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.

专利号:US-2004053355-A1
优先权日:2000-05-26
标题:Modular approach to on-line synthesis, drug discovery and biochemical transformations using immobilized enzyme reactors
发明人：WAINER IRVING; MARKOGLOU NEKTARIA
摘要:A coupled system using extremely different enzymes with incompatible cofactors and reaction conditions has been constructed using standard liquid chromatographic formats and open tubular formats. One of the significant aspects of the present invention lies in the development of the liquid chromatographic on-line enzyme cascade. This has been illustrated by the biosynthetic pathway involving dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase which encompass the synthesis of the key neurotransmitters, norepinephrine and epinephrine. The results demonstrate for the first time the immobilization of dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. The IMERs are active and can be used in a liquid chromatographic format for qualitative and quantitative determinations. The IMER-HPLC system can be used to carry out standard Michaelis-Menten enzyme kinetic studies and to quantitatively determine enzyme kinetic constants, identify specific enzyme inhibitors, provide information regarding the mode of inhibition and the inhibitor constants (K i ). A second significant aspect of the present invention lies in the ability of the immobilized enzyme reactors to be used independently or as a combination, thus providing a unique opportunity to explore the interrelationships between these enzymes, to investigate the source of diseases and to design new drug entities for identified clinical syndromes.

专利号:US-2003004337-A1
优先权日:2000-05-04
标 题 :Efficient lactam synthesis
发明人：JUNG KYUNG WOON; YOON CHEOL HWAN
摘要:Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a γ-lactam, in which an a-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C-H insertion, for example in the presence of a rhodium salt such as Rh 2 (OAc) 4 , n n n by which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.

专利号:US-6689890-B2
优先权日:2000-05-04
标 题:Efficient lactam synthesis
发明人：JUNG KYUNG WOON; YOON CHEOL HWAN
权利人:UNIV SOUTH FLORIDA
摘要:Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a gamma-lactam, in which an alpha-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C-H insertion, for example in the presence of a rhodium salt such as Rh2(OAc)4,by which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.