CAS: 66946-81-4; 3-Fluoro-1H-Indole

上下游产品

3,3-difluoro-1,3-dihydro-2H-indol-2-one indole-2,3-dione 1H-indole-3-carboxylic acid

📜3-吲哚甲酸置于lithium Acetate,Selectfluor体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应 15.0H,以14%的收率获得产物3-氟吲哚
参考文献:Selectfluor对富含电子的杂芳族羧酸进行脱羧氟化
标题:Selectfluor对富含电子的杂芳族羧酸进行脱羧氟化
摘要:富电子的五元杂芳族化合物(包括呋喃,吡唑,异恶唑,噻吩,吲哚,苯并呋喃和吲唑羧酸)与selectfluor的无过渡金属脱羧氟化反应得到了报道.观测到氟化二聚体产物中含氮杂芳族羧酸,例如吲哚和吡唑.已经开发出有效的方法,以在低温下以li 2 Co 3为碱合成2-和3-氟吲哚的单体.
DOI:10.1021/acs.Orglett.7B00335

专利信息

专利号:US-2023010886-A1
优先权日:2019-09-23
标 题 :Shp2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SUZHOU PUHE BIOPHARMA CO LTD
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-10561655-B2
优先权日:2018-03-21
标 题 :SHP2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SYNBLIA THERAPEUTICS INC
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.