CAS: 6385-02-0; Sodium 2-((2,6-Dichloro-3-Methylphenyl)Amino)Benzoate

该化合物是一种非类固醇抗炎药物,具有强效止痛,抗热和抗炎特性.作为中子素酸的钠盐,该钠与自由酸形式相比,其溶性和生物利用率有所提高.这一复合功能通过抑制环氧基酶(COX)酶,从而减少了丙烯酸合成.它通常用于研究和药物应用,研究炎症途径和开发治疗剂.其高纯度和稳定性使其适合分析和临床前研究.由于该钠在实验模型中具有一贯性,因此该钠在药理研究中提供了可靠的再生能力,因此特别值得注意.

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CAS号644-62-2 甲氯芬那酸

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    专利号:US-5922335-A
    优先权日:1995-05-15
    标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
    发明人:PTCHELINTSEV DMITRI
    权利人:AVON PROD INC
    摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.

    专利号:US-2007203079-A1
    优先权日:2005-11-21
    标题:Methods of using small molecule compounds for neuroprotection
    发明人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
    权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
    摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.

    专利号:AU-2015240775-A1
    优先权日:2014-04-01
    标 题 :Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof

    专利号:US-2021290651-A1
    优先权日:2020-03-20
    标 题:Methods of treating viral infections using inhibitors of nucleotide synthesis pathways

    专利号:US-2021308117-A1
    优先权日:2020-03-20
    标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways

    专利号:US-2021315880-A1
    优先权日:2020-03-20
    标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
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    主要参考文献


    1: Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016 May;94:131-44. doi: 10.1016/j.yjmcc.2016.03.016. Epub 2016 Apr 3. Review.

    合成参考文献


    参考文献:10.1371/journal.pone.0218897
    摘要:Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PLoS ONE. 2019 Jul 05;14(7):e0218897. doi: 10.1371/journal.pone.0218897.
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