专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-2024084356-A1 优先权日:2021-01-23 标题 :Ribosomal rna scaffolds for protein-free and template-free synthesis of peptides 发明人:WANG YUHONG; XU DORIS 权利人:UNIV HOUSTON SYSTEM 摘要:Embodiments of the present disclosure pertain to methods of synthesizing a peptide by associating at least one isolated ribosomal RNA (rRNA) fragment with a plurality of transfer RNA fragments linked to amino acids (tRNA fragments). The at least one rRNA fragment includes at least one domain that associates with the tRNA fragments. The at least one rRNA fragment catalyzes the synthesis of the peptide through peptidyl transfer of the amino acids from the tRNA fragments independently of messenger RNA (mRNA) templates. Additionally, the peptidyl transfer occurs independently of proteins. Further embodiments of the present disclosure pertain to systems for synthesizing a peptide. Such systems include the rRNA fragments of the present disclosure and optionally a plurality of tRNA fragments.
专利号:US-10814013-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:WO-2025019943-A1 优先权日:2023-07-24 标题:Small molecule ice recrystallization inhibitors and methods of use thereof 发明人:BEN ROBERT N; DIAMANTE MARCUS 权利人:UNIV OTTAWA 摘要:The present application provides ice recrystallization inhibitors, and methods of synthesis and use thereof. The ice recrystallization inhibitor (IRI) compounds have the structure of Formula (A) where B is an alkyl, or substituted or unsubstituted phenyl. The IRI compounds exhibit good IRI activity and are soluble in water and in buffers, such as those used in cryopreservation.
专利号:AU-2007308022-A2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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合成参考文献
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