CAS: 541-42-4; Isopropyl Nitrite

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Isobutyric Acid Sodium Salt置于sodium Nitrate,Sodium Carbonate体系中,化学反应生成 亚硝酸异丙酯
参考文献:Severe Prolonged Tacrolimus Overdose With Minimal Consequences
标题:Severe Prolonged Tacrolimus Overdose With Minimal Consequences
摘要:一名59岁的男性偶然间将每日两次口服的他克莫司剂量从1毫克增加到了10倍,导致其血药浓度在一周内超过90 Ng/ml.该患者因糖尿病导致终末期肾病,并在3个月前接受了来自女儿的肾脏移植.尽管他克莫司常见的不良反应包括轻度肾毒性,恶心,震颤和肝酶水平升高,但我们的患者在急性但长期的过量情况下,仅出现了轻微的毒性迹象和症状.然而,应该向所有接受他克莫司治疗的患者及其医生,护士和药剂师提供关于准确剂量,密切监测,潜在药物相互作用以及各种胶囊颜色的重要性教育,以尽量减少错误的发生.
DOI:10.1592/phco.22.12.1063.33604

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2006178357-A1
优先权日:2005-02-10
标题 :Chphalosporin-derived mercaptans as inhibitors of serine and metallo-beta-lactamases
发明人：BUYNAK JOHN D; CHEN HANSONG
权利人:BUYNAK JOHN D; CHEN HANSONG
摘要:Compounds of formula I: See Formula I in Figures Section n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-7125986-B2
优先权日:1997-12-29
标题:Penicillanic acid derivative compounds and methods of making
发明人：BUYNAK JOHN D; RAO AKIREDDY SRINIVASA; DOPPALAPUDI VENKATA RAMANA
权利人:UNIV SOUTHERN METHODIST
摘要:Compounds of formula I: n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-3697597-A
优先权日:1968-09-21
标 题:Process for the preparation of alpha-oximinoalkyl ketones
发明人：DORLARS ALFONS
权利人:BAYER AG
摘要:Alpha -Oximino ketones, for example, oximinodipropyl ketone, are prepared by reacting a ketone in an inert organic solvent immiscible with water in the presence of a hydrogen halide with an amount of alkyl nitrite that is insufficient for complete nitrosation followed by extracting the ketone formed with an aqueous alkali solution, removing the alkaline extract formed and isolating the Alpha -oximino ketone. The ketones formed are useful as intermediates in the synthesis of pharmaceutical compounds, dyes, analytical reagents, plant protection agents, and optical brighteners.

专利号:US-9181203-B2
优先权日:2010-11-12
标题:Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarbonitriles and substituted pyrazinecarboxamides
发明人：NAKAMURA KOUKI; MURAKAMI TAKESHI; NAITOU HIROYUKI; HANAKI NAOYUKI; WATANABE KATSUYUKI
权利人:FUJIFILM CORP; TOYAMA CHEMICAL CO LTD
摘要:The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): n nwherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(â•?O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.

专利号:RU-1589598-C
优先权日:1987-12-01
标题 :4-hydroxy-2,6-dihydroxyiminocyclohexanone as a parent product for synthesis of 4-hydroxybenzofurazan, and a method of 4-hydroxybenzofurazan synthesis