CAS: 498-59-9; L-Djenkolic Acid

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CAS号50-00-0 甲醛 | CAS号52-90-4 L-半胱氨酸 | CAS号75-09-2 二氯甲烷 | CAS号50-00-0 甲醛 | CAS号921-01-7 D-半胱氨酸 | CAS号56-89-3 L-胱氨酸 | CAS号51977-21-0 噻唑烷-4-甲酸乙酯

📜L-半胱氨酸,二氯甲烷置于氨体系中,化学反应生成 甲烯胱氨酸
参考文献:Du Vigneaud; Patterson,Journal Of Biological Chemistry,1936,Vol. 114,P. 533,537
标题:Du Vigneaud; Patterson,Journal Of Biological Chemistry,1936,Vol. 114,P. 533,537

专利信息

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-6117974-A
优先权日:1991-10-02
标题:Libraries of backbone-cyclized peptidomimetics
发明人：GILON CHAIM; HORNIK VERED
权利人:PEPTOR LTD; YISSUM RES DEV CO
摘要:Libraries of novel backbone-cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N(((-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N(((-functionalized) amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by libraries of backbone-cyclized bradykinin analogs, somatostatin analogs, BPI analogs and Substance P analogs having biological activity. Further embodiments of the invention are Interleukin-6 receptor derived peptides having ring structures involving backbone cyclization.

专利号:US-2006052577-A1
优先权日:2001-02-06
标题:Methods of synthesis of polymers and copolymers from natural products
发明人：SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
权利人:SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
摘要:Described are polymers and copolymers containing sorbitol, citric acid, starch, aspartic acid, succinic anhydride, adipic acid mixtures thereof, methods of their synthesis and their uses.

专利号:US-8378072-B2
优先权日:2006-04-13
标题 :Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
发明人：BONNIN DUSTAN
权利人:DECLION PHARMACEUTICALS INC; BONNIN DUSTAN
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.

专利号:US-6664368-B1
优先权日:1997-11-27
标题:Inhibition of nuclear import by backbone cyclic peptide analogs
发明人：FRIEDLER ASSAF; LOYTER ABRAHAM; GILON CHAIM; WOLF AMNON
权利人:YISSUM RES DEV CO; PEPTOR LTD
摘要:The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immunodeficiency virus type 1 proteins MA, Vpr, Tat and NLS-like sequences of HIV-1 protein Vif. We disclose the discovery of a novel, highly potent backbone cyclic peptide, designated BCvir, which inhibits nuclear import with an IC50 value of 35 nM. This inhibitory potency is to be compared to 12 muM exhibited by the linear parent HIV-1 MA NLS peptide. BCvir also reduced HIV-1 production by 75% in infected non-dividing cultured human T-cells and was relatively resistant to tryptic digestion. These properties render backbone cyclic peptide analogs of NLS or NLS-like sequences as candidates for novel drugs based on blocking nuclear import of viral genomes.

专利号:US-8697032-B2
优先权日:2003-05-02
标题:Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals
发明人：HUNTER DUNCAN; GAGNON M KAREN J
权利人:UNIV WESTERN ONTARIO
摘要:The present invention relates to compositions and methods for preparing radiopharmaceutical compounds in high chemical-purity and isotopic-purity. The present invention provides polymer-bound precursors to radiopharmaceutical compounds that can be converted to radiopharmaceutical compounds in one step. In a preferred embodiment, a radiopharmaceutical precursor is bound to a polymeric support via a prosthetic group comprising an alkenyl-tin bond. The radiopharmaceutical precursor is converted to a radiopharmaceutical compound in one step involving cleavage of the alkenyl-tin bond and incorporation of a radioisotope to form the radiopharmaceutical compound. Importantly, the polymeric support containing the toxic tin by-product can be easily removed from the radiopharmaceutical compound by filtration. The present invention can be used to install a large number of different radioisotopes. In a preferred embodiment, the radioisotope is 211 At, 123 I, or 131 I.