CAS: 3796-24-5; 4-(Trifluoromethyl)Pyridine

该化合物是一种氟化的环环环化合物,在四点方位上以三氟甲基组替代了一条环状,这种结构形态具有独特的电子和静态特性,使其成为制药,农用化学和材料化学中有价值的中间体.三氟甲基组增进了亲脂性和代谢稳定性,而环则有助于协调和氢燃烧能力.在交叉相交和核循环替代反应中具有高度的再活动性,可以实现多种功能化.该化合物在生物活性分子和先进材料合成方面特别有用,因为其电回推效应和化学强度是有利的.由于潜在的回流性和挥发性,需要妥善处理.

结构式图片

相似化合物

118078-66-3 3796-23-4 175205-81-9

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

  • 合成目标产物 4-(Trifluoromethyl)Pyridine 主要起始原料 4-Hydroxy-4-(Trifluoromethyl)Hepta-1,6-Diene
  • (文献来源)合成步骤主要原料 4-Hydroxy-4-(Trifluoromethyl)Hepta-1,6-Diene
4-(Trifluoromethyl)Pyridine N-Oxide置于苯硅烷,3-甲基-1-苯基-2-磷杂环戊烯-1-氧化物体系中,用 乙腈 作为反应溶剂,化学反应 16.0H,以93%的收率获得产物4-三氟甲基吡啶
参考文献:胺氮氧化物的无金属脱氧:合成和机理研究
标题:胺氮氧化物的无金属脱氧:合成和机理研究
摘要:我们在此报告了一种前所未有的光和 P(Iii)/p(V) 氧化还原循环的组合,用于芳香胺n-氧化物的有效脱氧.此外,我们发现仅使用苯基硅烷就可以轻松地对多种脂肪胺n-氧化物进行脱氧.这些实际上简单的方法在无金属条件下可以很好地进行,耐受许多功能并且具有高度的化学选择性.结合实验和计算研究,能够深入了解控制芳香族和脂肪族胺n-氧化物反应性的因素.
DOI:10.1002/cphc.202100108

海关参考信息

专利信息


专利号:US-10011567-B1
优先权日:2017-03-09
标题 :Method for the synthesis of acrylate derivatives
发明人:WANG MINGWEN; ZHANG YUE
权利人:INNOSCI LLC
摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.

专利号:WO-2025122636-A1
优先权日:2023-12-04
标题:Method for the synthesis of acrylate derivatives
发明人:CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN
权利人:ORTHOBOND CORP
摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人:RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-2023109627-A1
优先权日:2019-11-14
标 题:Precursor chemistry for quantum dot synthesis enabling temperature-independent modulation of reactivity
发明人:HAN HEE-SUN; PARK JOONHYUCK
权利人:UNIV ILLINOIS
摘要:Provided herein are methods of making a high-quality quantum dot (QD), including by providing anion precursor chemistry that enables chemical modulation of precursor reactivity, thereby, allowing independent optimization of reaction temperature and precursor reactivity to systematically grow high quality QDs and by providing specially configured tunable precursors and related chemistry to facilitate separate reaction pathways for nucleation and growth, thereby accessing heat-up based synthesis of high-quality QD, including core-shell QDs. The methods may include providing a base-QD and a first anion or cation precursor having a composition comprising an anion or a cation element, respectively, and a modification agent. At least one add-layer is grown on the base-QD at a growth temperature, thereby making the high-quality QD comprising the base-QD and the at least one add-layer. At least one add-layer may have a composition comprising an add-layer cation element and an add-layer anion element.

专利号:EP-1105359-B1
优先权日:1998-08-21
标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
发明人:CHATURVEDI SURENDRAKUMAR
权利人:PE CORP NY
摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.

专利号:US-5591867-A
优先权日:1992-12-04
标 题 :Synthesis of kainic acid
发明人:MONN JAMES A
权利人:LILLY CO ELI
摘要:This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.
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主要参考文献

[参考文献]: Cheng-Pan Zhang, Et Al. Copper-Mediated Trifluoromethylation Of Heteroaromatic Compounds By Trifluoromethyl Sulfonium Salts. Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1896-900.

合成参考文献


摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 355.
摘要:Chan, W.-W.; Yu, W.-Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 106.
摘要:André-Joyaux, E.; Gnägi, L.; Meléndez, C.; Soulard, V.; Renaud, P., Science of Synthesis, (2021) , 486.
摘要:Ouyang, Y.; Shou, J.-Y.; Qing, F.-L., Science of Synthesis: Special Topics, (2022) 1, 276.
摘要:Cheng, Q.; Shen, X., Science of Synthesis: Knowledge Updates, (2025) 2.
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