CAS: 2706-28-7; Sodium 2-Amino-5-((4-Sulfonatophenyl)Diazenyl)Benzenesulfonate

专利信息

专利号:US-3699146-A
优先权日:1970-03-31
标题:Synthesis of methyl malvalate and methyl 5,6-methano-5-undecenoate
发明人：GENSLER WALTER J
权利人:US AGRICULTURE
摘要:This invention relates to the preparation of methyl malvalate, methyl 5,6-methano-5-undecenoate and the preparation of some new intermediates. Malvalic acid, the major cyclopropene component in cottonseed oil, has been synthesized. When 1-chloro-7-hexadecyne reacts with diazoacetic ester in the presence of copper bronze, the ester of 1-chloro-7,8-carboxymethano-7-hexadecene is formed. Treating the corresponding acid chloride with zinc chloride causes loss of carbon monoxide. Either sodium borohydride or lithium aluminum hydride reduces the resulting cyclopropenium compound to 1-chloro-7,8-methano-7-hexadecene. Replacing the chloro group with cyano yields malvalonitrile, which can be converted to methyl malvalate. An analogous sequence of steps has been applied to 1-chloro-4-decyne to produce methyl 5,6-methano5-undecenoate. An alternate synthesis of methyl malvalate starts by using 1-chloro-7-hexadecyne as the precursor for methyl 8heptadecynoate. This acetylenic ester is converted to 8,9carboxymethano-8-heptadecenoic acid, the diacid chloride of which decarbonylates selectively in the presence of metallic chlorides to form the cyclopropenium-acid chloride. After esterification the resulting cyclopropenium-ester is reduced with borohydride to methyl malvalate.

专利号:US-2005112158-A1
优先权日:2003-11-17
标 题 :Method for synthesis of silylated ascorbic acid derivatives
发明人：TERRY W L JR; LEGROW GARY E; LITTAU CHERYL
权利人:CLARIANT INTERNATINONAL LTD
摘要:A compound of Formula (I), as defined in the specification, and a method for its synthesis. The method includes providing an inert environment, minimizing exposure of the reaction environment to visible light and reacting ascorbic acid with solvent and a compound of the Formula (II), as defined in the specification. The method of the present invention produces increased yields and a compound having increased stability and the same or greater bioactivity than ascorbic acid. The compound formed by the method of the present invention is capable for use in anhydrous cosmetic, dermatological and pharmaceutical compositions as an active agent for combating aging of the skin and improving its aesthetic appearance.

专利号:US-2023097824-A1
优先权日:2020-05-08
标 题:Semi-synthesis and use of racemic hematoxylin
发明人：DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR
权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC
摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.

专利号:US-2002039652-A1
优先权日:1996-04-29
标题:Synthesis of alumina acetate monohydrate salt sol fibers and uses thereof

专利号:US-2007015720-A1
优先权日:2005-02-04
标题 :Modulation of endogenous AICAR levels for the treatment of diabetes and obesity
发明人：BULOCK KAREN G; TEPPER MARK A; ZHANG JOHN Y; NABIOULLIN ROUSTEM R
权利人:CYTRX CORP
摘要:The invention relates to methods for treating type 2 diabetes, obesity, metabolic syndrome and conditions associated with these by administering an AICAR-monophosphate (AICAR-MP) enhancing agent that increases endogenous AICAR-MP levels in a cell. Inhibition of AICAR-formyltransferase activity (AICARFT) in a cell that regulates metabolic activity (such as fat, liver, muscle, pancreatic beta or certain brain cells) increases AICAR-monophosphate levels which in turn results in activation of the AMP-kinase (AMPK) pathway, and all of the downstream functions mediated by AMPK including increased fatty acid oxidation, enhanced glucose transport and decreased fatty acid synthesis.

专利号:US-4536776-A
优先权日:1981-10-05
标题:Ink-jet printing device
发明人：KNIRSCH FRANCO; GIANOLINI GIOVANNI; DAGNA GIAN D; BUAT MARIO
权利人:OLIVETTI & CO SPA
摘要:The device comprises a plurality of ink reservoirs, each connected to a number of nozzles (22) equidistant along a corresponding row. The nozzles connected to the various reservoirs are spaced apart vertically by at least one line space. The device can be used for printing different lines in parallel, moreover subdividing the length of the line, or for printing different zones of the sheet in facsimile. The ink is kept in circulation between the reservoirs and the nozzles by a common peristaltic pump which acts by a series of actuating elements on the discharge ducts for the inks in the reservoirs. The reservoirs may contain inks of different colors to permit printing in different colors or polychrome facsimile printing by additive or subtractive synthesis of the colors. The ink is conductive and is kept at earth potential, while electrodes (23) disposed outside the corresponding nozzles (22) are energized selectively to produce sprays of particles of ink from the nozzles. The ink contains a mixture of a dye of direct or solvent or acid type with a solution of water, electrolytic compounds, moistening agents, thickeners, preserving agents and antifoaming agent. The ink is prepared by mixing the compounds under agitation, then mixing in the dye until a predetermined acidity is obtained and finally filtering it and sealing it in the pack in the absence of air.