CAS: 227626-60-0; 2-(1-(((Tert-Butoxycarbonyl)Amino)Methyl)Cyclohexyl)Acetic Acid

该化合物是一种受保护的氨基酸衍生物,具有环氧基脊柱和三丁基碳基(Boc)组来保护地雷.Boc组在酸性和基本条件下增强稳定性,使其适合peptide合成和其他有机转化.环己基会有助于符合僵硬性,这对设计结构化中间体十分有利.箱式酸功能允许进一步衍生,有利于医药化学和材料科学的应用.这种复合体在需要选择性去保护和功能组相容的多步骤合成中特别有用.其定义完善的结构确保研究和工业过程中的可复制性.

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相似化合物

60142-96-3 882847-19-0 227626-62-2

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上下游产品

3-oxo-2-aza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester tert-butyl dicarbonatedi-tert-butyl dicarbonate H-Gpn-OH gabapentin-lactam tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 2-hydroxy-propyl ester[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 2-hydroxy-propyl ester tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 5-hydroxy-pentyl ester[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 5-hydroxy-pentyl ester tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 4-hydroxy-butyl ester[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 4-hydroxy-butyl ester tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 6-hydroxy-hexyl ester[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-acetic acid 6-hydroxy-hexyl ester

合成工艺路线路线简述

    📜3,3'-亚戊烯基-4-丁内酰胺置于4-二甲氨基吡啶,Lithium Hydroxide,水体系中,用 四氢呋喃,乙腈 用作溶剂,化学反应 6.0H,反应生成[1-(叔丁氧基羰基氨基-甲基)-环己基]-乙酸
    参考文献:Rigidified Compounds For Modulating Heparanase Activity
    标题:Rigidified Compounds For Modulating Heparanase Activity
    摘要:揭示了一种新颖的刚性化合物,其具有类似罗丹啉的残基和至少一个连接到类似罗丹啉残基的芳基或杂芳基残基,其中这些化合物的核心结构,如规范中定义的那样,其特征是具有一个或零个可自由旋转的键.还披露了含有这些刚性化合物的药物组合物以及用于调节肝素酶活性的用途,从而治疗与肝素酶相关的疾病和紊乱,并用于调节肝素结合蛋白的活性以及治疗与肝素结合蛋白相关的疾病和紊乱,以及治疗至少部分可通过罗丹啉或罗丹啉类似物治疗的医疗状况的用途.

    海关参考信息

    专利信息


    专利号:US-7423169-B2
    优先权日:2001-06-11
    标 题:Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
    发明人：RAILLARD STEPHEN P; ZHOU CINDY X; YAO FENMEI; MANTHATI SURESH KUMAR; XIANG JIA-NING; GALLOP MARK A
    权利人:XENOPORT INC
    摘要:The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.

    专利号:US-2013046012-A1
    优先权日:2010-04-28
    标题 :New compounds, synthesis and use thereof in the treatment of pain
    发明人：DEL CASTILLO NIETO JUAN CARLOS; MOURELLE MANCINI MARISABEL; PUBILL COY FRANCISCO; REPOLLES MOLINER JOSE
    权利人:LACER SA; DEL CASTILLO NIETO JUAN CARLOS; MOURELLE MANCINI MARISABEL; PUBILL COY FRANCISCO; REPOLLES MOLINER JOSE
    摘要:The present invention relates to compounds of formula (I), or pharmaceutically acceptable, stereoisomers, salts or solvates thereof n n n n n n n n n n to methods for their synthesis, and use in the treatment of pain.

    专利号:US-7232924-B2
    优先权日:2001-06-11
    标题 :Methods for synthesis of acyloxyalkyl derivatives of GABA analogs

    专利号:US-2008058546-A1
    优先权日:2001-06-11
    标题:Methods for Synthesis of Acyloxyalkyl Derivatives of GABA Analogs

    专利号:US-2006287250-A1
    优先权日:2001-06-11
    标 题:Methods for synthesis of acyloxyalkyl derivatives of GABA analogs

    专利号:JP-2005529941-A
    优先权日:2002-06-11
    标 题:Method for the synthesis of acyloxyalkyl derivatives of GABA analogs

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Decarboxylative 1,4-Carbocyanation Of 1,3-Enynes To Access Tetra-Substituted Allenes Via Copper/photoredox Dual Catalysis
    作者:Ya Chen,Junjie Wang,Yixin Lu
    摘要:An Efficient Synthesis Of Multi-Substituted Allenes By Metallaphotoredox-Catalyzed Decarboxylative 1,4-Carbocyanation Of 1,3-Enynes Is Described.

    合成参考文献


    摘要:Das, A.; Ramkumar, N.; Veliks, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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