CAS: 2165-19-7; 1-((2,3-Dihydrobenzo[b][1,4]Dioxin-2-yl)Methyl)Guanidine

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CAS号1094-91-3 2-羟甲基-1,4-苯并二噁烷... | CAS号128318-80-9 2-azidomethyl-2... | CAS号3663-82-9 2-羟甲基-1,4-苯并二恶烷 | CAS号247226-20-6 DiB°C guanoxan | CAS号4442-59-5 2-氨甲基-1,4-苯并二噁烷

📜2-Azidomethyl-2,3-Dihydro-1,4-Benzodioxine置于palladium On Activated Charcoal 氢气,四氯化锡,三乙胺体系中,化学反应生成胍生
参考文献:N-Hydroxyl Derivatives Of Guanidine Based Drugs As Enzymatic No Donors
标题:N-Hydroxyl Derivatives Of Guanidine Based Drugs As Enzymatic No Donors
摘要:Recent Research Suggests That No May Play A Role In The Physiological Effects Of Some Guanidine-Containing Drugs. In This Guanethidine Together With Their N-Hydroxyl Derivatives Were Report,Three Guanidine-Containing Drugs (Guanadrel,Guanoxan,And Guanethidine) Together With Their N-Hydroxyl Derivatives Were Synthesized And Their No-Releasing Abilities Catalyzed By Nitric Oxide Synthases (Noss) And Horseradish Peroxidase Were Evaluated. The Guanidine Containing Compounds Could Not Release No In The Presence Of Nos Or Peroxidase. The Corresponding N-Hydroxyl Compounds Exhibited Weak No-Releasing Ability Under The Catalyzed Of Nos And Good No-Releasing Ability Tinder The Oxidation By Horseradish Peroxidase In The Presence Of H2O2. These Compounds Also Displayed Vasodilatory Activity. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(01)00456-5

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-4781866-A
优先权日:1985-03-15
标题 :Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.