专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-4460793-A 优先权日:1980-12-30 标 题:Preparation of monochloromethyl ketones 发明人:JAUTELAT MANFRED; ARLT DIETER; JAEGER GERHARD 权利人:BAYER AG 摘要:A process for the production of a monochloromethyl ketone of the formula in which R1, R2 and R3 each independently is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkinyl or aryl radical, or R1 and R2 together with the carbon atom to which they are attached form an optionally substituted carbocyclic ring, comprising reacting a 1,1-dichloroalkene of the formula with a phenolate of the formula in which R4 each independently is a halogen atom, a nitro group, or an optionally substituted alkyl, alkoxy or aryl radical, n is 0, 1, 2 or 3, and M is one equivalent of an alkali metal ion or alkaline earth metal ion, thereby to obtain a phenyl ether intermediate, and then subjecting the phenyl ether intermediate to an acid hydrolysis. The products are useful as intermediates in the synthesis of fungicides.
专利号:US-6576782-B1 优先权日:1999-04-08 标 题 :Halogenation of protected phenols in meta position 发明人:DESMURS JEAN-ROGER; PADILLA GENEVIIVE; SPINDLER JEAN-FRANCIS 权利人:RHODIA CHIMIE SA 摘要:The invention concerns a halogenation in position meta of a phenol fuction. Said halogenation comprises a step which consists in halogenating an aromatic derivative of a medium or advantageously strong acid, the aromatic radical being a phenyl substituted in ortho and in para by functions attracting electrons by inductive effect. The invention is applicable to organic synthesis.
专利号:CN-109134204-A 优先权日:2018-11-16 标 题:Synthesis of intermediate 2-bromo-4-fluoro-5-chlorophenol
专利号:CN-111072615-A 优先权日:2019-11-08 标题 :Synthesis of 3- (1-aminoethylidene) -6-methyl pyran-2, 4-dione derivative and application thereof as herbicide
专利号:RU-2038351-C1 优先权日:1990-07-17 标题 :Benzene derivatives containing heterocycle, methods of their synthesis, and herbicide agent
[参考文献]: Inna P Solyanikova, Et Al. Conversion Of 2-Fluoromuconate To Cis-Dienelactone By Purified Enzymes Of Rhodococcus Opacus 1Cp. Appl Environ Microbiol. 2003 Sep;69(9):5636-42.
合成参考文献
参考文献:10.1134/s1070328422700312 摘要:Efremov AN, Sharutin VV. Oxidation of Tris(5-bromo-2-methoxyphenyl)antimony by tert-Butyl Hydroperoxide in the Presence of Compounds Containing an Active Hydrogen Atom. Russ J Coord Chem. 2023 Jan;49(1):47–55. doi: 10.1134/s1070328422700312.