CAS: 15026-80-9; 1-Pentanamidocyclopentanecarboxylic Acid

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CAS号194984-24-2 N- (1- cyano cy... | CAS号638-29-9 正戊酰氯 | CAS号52-52-8 环亮氨酸 | CAS号141745-71-3 N-[(2'-Cyano[1,... | CAS号138402-11-6 厄贝沙坦 | CAS号138402-10-5 三苯甲基依贝沙坦 | CAS号138401-24-8 2-丁基-3-[[2'-氰基-...

📜1-氨基环戊烷腈盐酸盐置于盐酸,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 4.67H,反应生成N-戊酰基氨基环戊烷-1-羧酸
参考文献:Improved Methods For The Synthesis Of Irbesartan,An Antihypertensive Active Pharmaceutical Ingredient
标题:Improved Methods For The Synthesis Of Irbesartan,An Antihypertensive Active Pharmaceutical Ingredient
摘要:
Doi:10.1080/00397910701471279

专利信息

专利号:US-7741492-B2
优先权日:2005-02-28
标题:Method for obtaining a pharmaceutically active compound (Irbesartan) and its synthesis intermediate
发明人：HUGUET CLOTET JOAN; DALMASES BARJOAN PERE
权利人:INKE SA
摘要:It is provided a method for obtaining Irbesartan polymorph A, with few synthesis steps, by coupling the intermediate of formula (II) with the compound of formula (III), neutralising one of its alkaline salts in an aqueous medium and recrystallising the crude product obtained. The utilisation of said method obviates protection and deprotection of the tetrazole ring and is therefore of considerable interest for obtaining Irbesartan on a large industrial scale. The invention also refers to the synthesis intermediate of formula (II).

专利号:ES-2310281-T3
优先权日:2003-02-05
标题:SYNTHESIS OF 2-BUTIL-3- (2 '- (1-TRITIL-1H-TETRAZOL-5-IL) BIFENIL-4-IL) -1,3-DIAZASPIRO-4,4-NONEN-4-ONA.

专利号:ES-2291099-A1
优先权日:2005-02-28
标题 :IMPROVEMENTS IN THE OBJECT OF THE MAIN PATENT NUM. 200500485, BY 'PROCEDURE FOR OBTAINING A PHARMACEUTICALLY ACTIVE COMPOUND AND ITS SYNTHESIS INTERMEDIATE'.